Pharma Focus Asia

Actym Therapeutics and Wacker Biotech Sign Manufacturing Contract for Actym's Lead Candidate for the Treatment of Solid Tumors

Tuesday, March 01, 2022

Actym Therapeutics, a biotechnology company focused on the discovery and development of novel therapies intended to transform the treatment of cancer, and Wacker Biotech announced today that they have signed a contract for the manufacturing of Actym's lead clinical candidate, ACTM-838, for the treatment of solid tumors.

Under the terms of the agreement, Wacker Biotech will initiate GMP (Good Manufacturing Practice) production of Phase 1 clinical material of Actym's therapeutic candidate at its site in Amsterdam using its LIBATEC® technology. Both companies announced today that they are already working closely together on technology transfer and initiation of scale-up production of ACTM-838.

ACTM-838 is Actym's lead clinical development candidate for the treatment of solid tumors. The therapeutic candidate is based on the company's immunotherapy platform called STACT (S. Typhimurium-Attenuated Cancer Therapy), which delivers active compounds directly to tumor-resident immune cells. "Manufacturing of ACTM-838 is an important milestone for our company. We are excited to work with Wacker Biotech given their significant experience manufacturing GMP-compliant, live microbial products in a closed production system," said Christopher Thanos, PhD, Actym's President and Chief Executive Officer. "Wacker Biotech's expertise in large-scale, high-quality microbial manufacturing is a perfect fit for production of therapeutic candidates for clinical testing from Actym's state-of-the-art STACT platform."

Wacker Biotech is a contract development and manufacturing organization (CDMO) pooling the biopharmaceuticals activities of the WACKER Group. Wacker Biotech will use its LIBATEC® technology platform for live microbial products (LMPs) in the project. "We are pioneers in the field of LMP production, having begun LMP contract manufacturing at our Amsterdam site in 2006," said Jörg Lindemann, Managing Director of Wacker Biotech B.V. "Our LIBATEC® platform can be used for a wide range of LMPs. It is perfectly suited to supporting Actym with their STACT platform." Besides GMP-compliant process development and manufacturing, LIBATEC® will be used for the development of analytical methods.

magazine-slider-imageMFA + MMA 2024CPHI Chine || PMEC China 2024Asia Healthcare Week 2024CPHI Korea 2024CHEMICAL INDONESIA 2024INALAB 2024 Thermo Scientific - DynaDrive and DynaSpinDigital Health Asia 2024ISPE Singapore Affiliate Conference & Exhibition 2024Rehab Expo 20242024 PDA Pharmaceutical Manufacturing & Quality Conference2024 PDA Cell and Gene Pharmaceutical Products Conference 2024 PDA Aseptic Manufacturing Excellence Conference2024 PDA Aseptic Processing of Biopharmaceuticals ConferencePharma Quality Excellence Awards 20244th Annual Pharma GMP Quality Management 20243rd World ADC Asia 2024LogiPharma Asia 2024