Pharma Focus Asia

Arecor and TRx BioSciences Establish Partnership for Advancing Oral GLP-1 Therapy with Improved Bioavailability

Wednesday, March 13, 2024

Arecor Therapeutics plc (AIM: AREC), a biopharmaceutical company focused on advancing modern therapies for improved health outcomes, has teamed up with TRx Biosciences Limited, a leader in innovative lipid technology for oral drug delivery. Together, they have announced a research collaboration aimed at formulating an oral glucagon-like peptide-1 (GLP-1) receptor agonist product.

GLP-1 receptor agonists are crucial for managing type 2 diabetes and obesity. The global market for these treatments is projected to reach $80-$100+ billion by 2030. However, delivering these drugs orally presents significant challenges due to the digestive system's proteolytic nature, resulting in reduced bioavailability. Currently, injection remains the primary delivery method, limiting patient adoption, compliance, and usage.

The only oral GLP-1 receptor agonist available to patients is Novo Nordisk’s semaglutide (Rybelsus®), which boasts less than 1% oral bioavailability. To address this issue, Arecor and TRx Biosciences plan to utilize TRx Biosciences’ LipiCore™ oral delivery technology along with Arecor’s formulation platform, Arestat™. This collaboration aims to develop an oral GLP-1 receptor agonist product with improved physicochemical properties to achieve higher oral bioavailability and stability.

Sarah Howell, CEO of Arecor, highlighted the ongoing challenges in oral delivery for GLP-1 receptor agonists and expressed optimism in leveraging Arecor's Arestat™ technology alongside TRx Biosciences' expertise to develop an enhanced oral product. Dr. Robin Bannister, CEO of TRx Biosciences, emphasized the importance of effective oral peptide delivery and the potential of combining LipiCore™ with Arecor's platform to unlock novel oral uptake channels and protect peptides during gastrointestinal transit.

The collaboration aims to extend beyond the initial GLP-1 receptor agonist program to develop additional oral peptide products, potentially targeting obesity-related health conditions and other therapeutic areas. Success in this endeavor could revolutionize oral peptide therapy, providing patients with more convenient and effective treatment options.



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