Pharma Focus Asia

Chime Biologics Announces Strategic Cooperation with Leads Biolabs and BeiGene

Saturday, July 01, 2023

Chime Biologics, Leads Biolabs, and BeiGene have formed a strategic cooperation to accelerate the development and manufacturing of LBL-007, a novel antibody targeting the LAG-3 pathway.

The three parties have formed a comprehensive strategic partnership, grounded in the principles of leveraging complementary advantages, sharing resources, fostering a strong alliance, and promoting win-win cooperation. Their collaboration aims to accelerate the clinical trial process of LBL-007 and advance multiple clinical studies worldwide.

This strategic cooperation between the three companies signifies their commitment to pooling resources, expertise, and capabilities to expedite the development, manufacturing, and distribution of LBL-007, ultimately aiming to bring this innovative antibody to patients in need.

LBL-007 is a fully humanised monoclonal antibody that specifically targets LAG-3 (lymphocyte activating gene-3), a protein involved in regulating immune responses. It is composed of two IgG4 heavy chains and two κ light chains linked by disulfide bonds. LBL-007 binds with high affinity to human LAG-3 and acts by blocking LAG-3's activation of immune function.

In preclinical models, LBL-007 has been studied in combination with another antibody called anti-programmed cell death protein 1 (PD-1). By combining LBL-007 with anti-PD-1, researchers have observed synergistic antitumor activity.

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