Pharma Focus Asia

Constant Pharmaceuticals, LLC Announces Japanese Patent Issuance for TXA302 in Treatment of Stroke

Wednesday, March 07, 2018

Constant Pharmaceuticals LLC, a privately held biopharmaceutical company focused on the treatment of stroke recovery, today announced that the Japanese Patent Office has issued a patent covering the use of TXA302 in the treatment of stroke. TXA302 is a proprietary analogue of the naturally occurring peptide Angiotensin (1-7).

"The issuance of this Japanese patent, combined with the already issued U.S. patent, strengthens our IP position around stroke and stroke recovery, where there remains significant, unmet medical need," said Richard Franklin, President and Chief Executive Officer of Constant Pharmaceuticals LLC.

About 800,000 new cases of stroke occur annually in the U.S and over 200,000 new cases in Japan. Approximately 3.5 million stroke survivors in U.S. have ongoing mobility issues, and there are no currently approved medications for such impairments.

Previous Constant research has shown that TXA302 improves functional recovery across all endpoints in three different rat models of stroke recovery. Additionally, the functional recovery is correlated to an increase in blood flow and capillary density. TXA302 is an analogue of Angiotensin (1-7), which is part of an alternative pathway of the renin-angiotensin system. Constant research suggests that TXA302 achieves its effects on angiogenesis and plasticity in the brain by stimulating endothelial progenitor cells and oligodendrocyte progenitor cells, leading to increases in brain-derived neurotrophic factor and other factors. Seth Finkelstein, MD, PhD, Advisory Board Chairman of Constant Pharmaceuticals stated, "TXA302's recent results using different models of stroke, where the peptide significantly improves functional recovery compared to control, is an exciting discovery. These results suggest that TXA302 might have potential use in the clinic." Constant Pharmaceuticals expects to initiate a Phase 2 clinical trial in stroke recovery in early 2019.

magazine-slider-imageMFA + MMA 2024CPHI Chine || PMEC China 2024Asia Healthcare Week 2024Advance DoE WorkshopNitrosamine Advance Workshop 2024CPHI Korea 2024CHEMICAL INDONESIA 2024INALAB 2024 Thermo Scientific - DynaDrive and DynaSpinDigital Health Asia 2024Rehab Expo 2024ISPE Singapore Affiliate Conference & Exhibition 20242024 PDA Pharmaceutical Manufacturing & Quality Conference2024 PDA Cell and Gene Pharmaceutical Products Conference 2024 PDA Aseptic Manufacturing Excellence Conference2024 PDA Aseptic Processing of Biopharmaceuticals ConferencePharma Quality Excellence Awards 20244th Annual Pharma GMP Quality Management 20243rd World ADC Asia 2024LogiPharma Asia 2024