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Menarini Silicon Biosystems launches new breakthrough DEPArray™ PLUS image-based cell sorter to isolate rare cells with single cell precision

Thursday, May 27, 2021

Menarini Silicon Biosystems, a pioneer of liquid biopsy and single cell technologies, announced today the launch of the new highly automated DEPArray™ PLUS*, now available with 9 fluorescent channels. This robust image-based cell-sorting technology combines microelectronics and microfluidics in a unique platform to isolate rare cells from mixed cellular samples. Its optimized, intuitive interface allows researchers to obtain the desired target cells with a 100% purity and minimal operator interaction. The built-in software leads to a rapid selection of cells with a high level of accuracy, reproducibility, and quality images thanks to its fluorescent microscope resolution. The system is compatible with a variety of rare cell suspensions, including live and fixed cells, small cell loads, Formalin-Fixed Paraffin-Embedded (FFPE) tissues and liquid biopsies. Sorting of rare cells with DEPArray PLUS has become more effortless and precise than ever before.

DEPArray PLUS additional fluorescent channels provide expanded capabilities to better characterize different cell populations from complex heterogeneous samples. Once individual or pools of cells are isolated, researchers can conduct precise molecular investigations. "The DEPArray PLUS can complement the CELLSEARCH® platform, the Gold Standard for circulating tumor cells enrichment, to perform further molecular analyses and clinical research using the captured CTCs, since it features a unique automated workflow to isolate cells with very limited operator intervention and improved standardization of the process," commented Professor Leon WMM Terstappen, MD, PhD, Chair of the Department of Medical Cell BioPhysics at the University of Twente, The Netherlands.

DEPArray PLUS is the latest evolution of the DEPArray technology with unique new features to optimize the user experience, reduce hands-on time and speed up sample processing. These include an automated notification system informing users directly on their mobile device upon the completion of each step of a run and a faster workflow thanks to a new cartridge with enhanced microfluidics and the implementation of pre-set parameters for identification and recovery of target cells.

Researchers have the flexibility to prepare their samples according to their own protocol or use optimized sample preparation kits for various inputs including blood, FFPE tissue and forensic evidence. The system is able to identify and isolate extremely low numbers of target cells from a minimal input sample volume. DEPArray PLUS is fully integrated with blood samples prepared with the Menarini Silicon Biosystems CTC enrichment technologies, CELLSEARCH® and CELLMAG™, allowing further isolation and delivery of 100% pure single cells ready for genetic analysis.

For Fabio Piazzalunga, President and CEO of Menarini Silicon Biosystems "We are proud to provide the new powerful version of DEPArray technology for rare cell sorting with full automation capability: it is a revolutionary platform on which we will continue to add innovative features thereby opening new horizons for patient-centered precision therapies"

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