Pharma Focus Asia

Otsuka Pharmaceutical and X-Chem Enter into a Drug Discovery Research and License Collaboration

Wednesday, December 20, 2017

Otsuka Pharmaceutical Co., Ltd. (Otsuka) and X-Chem, Inc. (X-Chem) announce that they have signed a collaborative research agreement to advance the discovery process for new Otsuka drug compounds.

Under the terms of the agreement, X-Chem will utilize its DNA-encoded library (DEXTM) screening and informatics platform to search for novel drug leads for several Otsuka discovery targets. X-Chem received an initial research fee from Otsuka upon the signing of the agreement, and is eligible for future payments based on the achievement of research and development milestones, as well as royalties and sales milestones on compounds identified under the collaboration that receive regulatory approval. Otsuka will furnish several target proteins to X-Chem, independently conduct clinical trials for any compounds identified, and retain exclusive rights to globally commercialize any products resulting from the collaboration.

The collaboration will deploy X-Chem’s DEXTM libraries containing more than 120 billion individually DNA-encoded compounds. The DNA encoding of molecules enables screening and analysis of vast chemical space, supporting Otsuka’s aim to increase success rates for the generation of target leads for new drugs and to shorten screening timelines.

Toshiki Sudo, executive director ?drug discovery? at Otsuka noted, "We are engaged in research and development of unique therapeutic drugs that are valuable to patients, particularly in disease areas related to the central nervous system, renal circulation, and in oncology. We anticipate that our drug discovery research will be further enhanced through X-Chem’s breakthrough technology, leading to the creation of innovative pharmaceuticals."

Rick Wagner, president and CEO of X-Chem commented upon the signing of the contract, "We are delighted to work with Otsuka, a company which itself has impressive discovery technologies, including their fragment-based discovery platform. Utilizing X-Chem’s DEXTM platform, we hope to help create additional pathways for Otsuka to uncover candidate compounds."

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