Pharma Focus Asia

Repare Therapeutics Announces a Strategic Partnership Agreement With ONO Pharmaceutical Co., Ltd.

Thursday, January 31, 2019

Repare Therapeutics, Inc., a privately held precision oncology company pioneering synthetic lethality to develop novel therapeutics that target specific vulnerabilities of tumors in clearly defined patient populations, announced today that it has entered into an exclusive strategic research, development and commercialization partnership with ONO Pharmaceutical Co., Ltd., for Repare’s small molecule Polθ inhibitor program in Japan, South Korea, Taiwan, Hong Kong, Macau and ASEAN countries, excluding mainland China. Repare retains all rights to develop and commercialize the products outside the ONO territory, including the US, Canada and EU.

“We’re excited to have ONO as a discovery and development partner,” said Lloyd M. Segal, President and CEO of Repare. “This relationship will support our drive to and through the clinic in this important new area of precision oncology therapeutic development.”

“ONO identified Repare Therapeutics as the partner of choice for bringing in a potential first-in-class and best-in-class Polθ inhibitor to our portfolio,” said Gyo Sagara, President, Representative Director and CEO of ONO. “We are excited to work with Repare for the benefit of cancer patients.”

Under the terms of the agreement, ONO will provide an up-front payment and research service payments potentially totaling US $15M, plus additional cost-sharing through IND. Beyond IND, significant clinical, regulatory and commercial milestones are also included in the agreement, with a potential total of US $160M. ONO will also pay to Repare high single-digit to low double-digit tiered royalties based on net sales of the products. Repare retains all rights to develop and commercialize the products outside the ONO territory, including the US, Canada and the EU.

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