Wednesday, September 28, 2022
A new ultra-compact sterile connector provides biopharmaceutical and cell and gene therapy manufacturers a much-needed alternative to tube welding for their small-volume closed aseptic processes. MicroCNX® Series Connectors are the newest addition to the suite of aseptic connection solutions from CPC, including AseptiQuik® Connectors. The new product is designed to provide a smaller, easier, faster and less risky method of connecting tubing for small-format assemblies.
“MicroCNX® connectors area critically important option for a range of bioprocessing, cell therapy and gene therapy workflows,” said Troy Ostreng, senior product manager for CPC’s biopharmaceutical business. “We hope to present a true alternative to the cumbersome process of tube welding, ending the hassle of the weld and enable operators to make sterile closed connections more efficiently. The MicroCNX® connector represents a huge innovation for the industry, in particular for those working with very small-bore tubing.”
MicroCNX® connectors are designed specifically for small-volume processes involving widely used 1/16” (1.6mm), 3/32” (2.4mm) and 1/8” (3.2mm) tubing. These include sampling, seed train expansion and early cell culture processes involving shaker flasks and rocker tables.
“The MicroCNX® series was designed to help manufacturers improve process efficiencies and reduce time and total cost in creating closed systems that deliver reliable, reproducible results,” said Ostreng.
Testing indicates that making a sterile connection with the new connector is up to four times faster than an operator using a tube welder.1 Meaning, in the time required to create one weld, up to four MicroCNX® connections could be completed. Multiply those numbers over the course of a year, and the operational efficiencies are clear.
The easy, three-step process for using MicroCNX® connectors requires minimal training. Users simply “Pinch-Click-Pull”: 1) pinch to remove the protective cover;2) click together the connector halves; and,3) pull out the protective membranes so flow can start. In comparison, tube welding involves a dozen or more steps, with operator challenges including maneuvering the tube welder into position, dealing with equipment maintenance, and requiring precise technique to create a successful weld. With MicroCNX® solutions, there is no risk of faulty welds, welder breakdowns, or production delays due to weld equipment downtime.
Use of aseptic connectors eliminates the need to purchase, calibrate, validate and maintain tube welders that can cost more than €12,700($15,000) each. Manufacturers often need multiple welders, which take up valuable space in a cleanroom.
“It’s expensive and time consuming to validate new space,” Ostreng noted. “MicroCNX® connectors can help biopharmaceutical and cell and gene therapy manufacturers make the most of their existing cleanroom space.”
In order to ensure a clear flow path, tube welding requires operators to manually restore the tubing’s shape after being crimped by a weld. In contrast, MicroCNX® connectors help deliver a consistent flow path with every connection. Because MicroCNX® connectors can be incorporated into pre-made tubing assemblies, operators know where to make connections—there’s no guesswork on their part, which supports current good manufacturing practices (cGMP). The size, weight and geometry of the new connector also fit well with the trend toward compact automated equipment for use in processes like cell expansion.
For more information about MicroCNX® Series Connectors and how tube welding and aseptic connectors compare, visit cpcworldwide.com/micro.
1. Data on file.
About CPC Biopharma
CPC (Colder Products Company) is a global leader in single-use connection technology, offering a wide variety of connectors for biopharmaceutical manufacturing. Innovative, flexible designs easily combine multiple components and systems including process containers, tubing manifolds, transfer lines, bioreactors and other bioprocess equipment. Robust single-use connectors maintain media sterility and integrity while improving production yields, decreasing time to market and reducing costs. The company’s well-known AseptiQuik® connectors provide quick and easy sterile connections even in non-sterile environments. Learn more about our entire portfolio at cpcworldwide.com/bio. Connect with confidence with CPC, an operating company within Dover Corporation.
CPC, Colder Products, Colder Products Company and Dover are registered trademarks with the U.S. Patent & Trademark office.
Jana Stender, CPC (U.S.) | Tel: +1 (612) 564-2053 | Email: email@example.com
Gu Xingzhi, Finn Partners (Singapore) | Email: firstname.lastname@example.org