The late-stage chronic kidney disease (CKD) - Induced Hyperparathyroidism, Hyperphosphatemia, and Hyperkalemia market is expected to undergo significant growth over the next ten years across the seven major markets (7MM) covered in this report (US, France, Germany, Italy, Spain, UK, and Japan). The main driver of this expansion will be the dramatic increase in disease prevalence. According to primary research, GlobalData has determined that there is a high level of unmet need remaining for CKD patients. Despite the launch of new agents, GlobalData expects significant opportunities to remain for developers of drugs with novel mechanisms of action. The challenge for new entrants will be getting a foothold in the dialysis care setting; in this regard, GlobalData anticipates that partnerships and agreements between manufacturers and dialysis centers will continue to be a key strategy to maintain dominance in this market.
This report will specifically focus on three major CKD-induced comorbidities: hyperparathyroidism (HPT), hyperphosphatemia (HP), and hyperkalemia (HK). The major barrier to CKD market growth over the 2016-2026 forecast period is the loss of patent exclusivity of major drugs in the HPT, HP space. However, the decline in sales will be countered by the launch of pipeline contenders, particularly Amgen’s Parsabiv (etelcalcetide), and Ardelyx’s tenapanor, which will aid global sales growth throughout the forecast period. Lastly, the arrival of new HK agents with preferable onsets of action, effectiveness, and safety, along with reduced compliance-associated issues, will steal significant market share from SOC HK therapies.