Cytiva and Cellular Origins Advance Cell & Gene Therapy with Robotic Manufacturing
Friday, January 17, 2025
Cytiva has partnered with Cellular Origins.
The collaboration aims to transform CGT production by integrating Cytiva’s automated Sefia platform with Cellular Origins’ robotic platform, Constellation.
This integration will enable manufacturers to scale production from research and clinical trial phases to industrial levels without altering established processes.
The two systems are designed for seamless digital connectivity, offering integrated quality control, remote digital operation, and advanced analytics. This approach minimises manual intervention, improving automation and manufacturing efficiency.
The current manufacturing processes for CAR-T therapies rely heavily on manual labour, contributing to complexity and variability. Limited production capacity, a high risk of batch failures, and increasing regulatory approvals for expanded indications pose additional challenges for meeting patient demand.
With only 47% of referred patients currently able to access CAR-T therapies, the need for industrial-scale solutions is critical.
The partnership between Cytiva and Cellular Origins aims to address these issues through a modular robotic approach. This system will allow manufacturers to scale production from thousands to hundreds of thousands of doses annually, enabling around-the-clock operations.
Customers will benefit from improved workflow integration without the need to redesign approved processes. Key advantages include optimised use of manufacturing space, reduced labour requirements, and lower production costs, which could help overcome significant barriers to patient access.
The first systems are expected to undergo process and biological testing in early 2025, with GMP-compliant versions anticipated by the end of the year for clinical applications.
This initiative marks a significant step towards industrialising CGT manufacturing and improving accessibility for patients globally.
Source: cytivalifesciences.com
