Integrated DNA Technologies Introduces New Enhancer Protein to Advance CRISPR-Based Therapies
Friday, September 26, 2025
Integrated DNA Technologies (IDT) has launched the Alt-R™ HDR Enhancer Protein, a new tool designed to improve the efficiency of homology-directed repair (HDR) in difficult-to-edit cells, such as induced pluripotent stem cells (iPSCs) and haematopoietic stem and progenitor cells (HSPCs).
The protein, manufactured by Aldevron to meet strict quality standards, has shown the potential to double HDR efficiency while maintaining cell viability and genomic stability. Importantly, it does not increase off-target edits or translocations.
CRISPR-Cas systems are widely used for generating knockouts, but knock-ins through HDR remain challenging. Studies with the Alt-R HDR Enhancer Protein have demonstrated significant improvements in HDR efficiency across different loci and cell types, offering a reliable solution for both research and translational applications.
The enhancer protein is available in research-use-only format in 500 μg and 5 mg quantities, with a CGMP grade version planned. It is compatible with multiple Cas systems and delivery methods, making it suitable for integration into existing workflows.
This launch strengthens IDT’s CRISPR portfolio, which spans from discovery to clinical applications, including Cas9 and Cas12a systems, customised guide RNAs, HDR solutions, and CGMP manufacturing. These tools continue to support the development of innovative gene editing therapies.
Source: idtdna.com
