Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Factors to consider in developing individual pharmaceutical product quality risk profiles useful to government procurement agencies
Abstract Governments that procure pharmaceutical products from an Essential Medicine List EML bear special responsibility for the quality of these products In this article we examine the possibility of developing a pharmaceutical product quality risk assessment scheme for use by government procurement officials We use the Chinese EML as a basis an...
Pharmaceutical interfaces: Drug development, performance, regulation and e-health
Interfaces have always been of concern with respect to the delivery of bioactives Interfaces within the delivery system that can affect stability are a concern however there are other interfaces of importance such as the interface with the body tissue the regulatory interface and the emerging interface when drug delivery is linked to ehealth applic...
Relation between safe use of medicines and Clinical Pharmacy Services at Pediatric Intensive Care Units
Abstract Objective Clinical Pharmacy Services CPS are considered standard of care and is endorsed by the Joint Commission International the American Academy of Pediatrics and the American College of Clinical Pharmacy In Brazil single experiences have been discreetly arising and the importance of these s
New frontiers in pharmaceutical analysis: A metabolomic approach to check batch compliance of complex products based on natural substances
Abstract Natural substances particularly medicinal plants and their extracts are still today intended as source for new Active Pharmaceutical Ingredients APIs Alternatively they can be validly employed to prepare medicines food supplements or medical devices The most adopted analytical approach used to verify quality of natural substances like med...
Role of sTREM-1 in predicting mortality of infection: a systematic review and meta-analysis
Abstract Objectives Several studies have investigated the prognostic value of soluble triggering receptor expressed on myeloid cells sTREM in patients with infection However the result was controversial Thus the purpose of the present metaanalysis was to determine the prognostic value of the sTREM
Biosensor-based engineering of biosynthetic pathways
Abstract Biosynthetic pathways provide an enzymatic route from inexpensive renewable resources to valuable metabolic products such as pharmaceuticals and plastics Designing these pathways is challenging due to the complexities of biology Advances in the design and construction of genetic variants has enabled billions of cells each possessing a sli...
The model beetle Tribolium castaneum can be used as an early warning system for transgenerational epigenetic side effects caused by pharmaceuticals
Abstract Pharmaceuticals are not currently tested for transgenerational and epigenetic side effects The use of vertebrates as preclinical research models is limited by their long generation times low numbers of progeny and ethical concerns In contrast invertebrates such as insects breed rapidly produce many offspring and are more ethically accepta...
What do pharmaceutical industry professionals in Europe believe about involving patients and the public in research and development of medicines? A qualitative interview study
Abstract Objectives To explore Europeanbased pharmaceutical industry professionals beliefs about patient and public involvement PPI in medicines research and development RD Setting Pharmaceutical companies in the UK Poland and Spain
Improving the management of multimorbidity in general practice: protocol of a cluster randomised controlled trial (The 3D Study)
Abstract Introduction An increasing number of people are living with multimorbidity The evidence base for how best to manage these patients is weak Current clinical guidelines generally focus on single conditions which may not reflect the needs of patients with multimorbidity The aim of the D study is to
Pharmaceutical treatments to prevent recurrence of endometriosis following surgery: a model-based economic evaluation
Abstract Objective Conduct an economic evaluation based on best currently available evidence comparing alternative treatments levonorgestrelreleasing intrauterine system depotmedroxyprogesterone acetate combined oral contraceptive pill COCP and no treatment to prevent recurrence of endomet
