Increase speed to market with right-sized cell culture from process development to commercialization with the Thermo ScientificTM DynaDriveTM SingleUse Bioreactor
Simplify your harvest process and drive savings with a sustainable, safe, and robust technology with the Thermo ScientificTM DynaSpinTM Single-Use Centrifuge
Upstream bioproduction has seen a substantial movement in the industry toward single-use systems. This has been driven primarily by the need to reduce contamination risk and cleaning requirements when compared to stainless steel systems, and to allow for faster changeover of equipment between batches. At the same time, bioprocessing manufacturing processes have matured significantly, and intensification of cell culture processes has pushed the limits of these legacy single-use systems.
Thermo Fisher Scientific™ has brought enhancements to the Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.) platform with 5:1 S.U.B. and enhanced S.U.B. options, which have allowed for higher turndown ratios and optimized mixing and gassing strategies for intensified processes. Now Thermo Fisher Scientific has launched a next-generation bioreactor for the biopharmaceutical industry with the Thermo Scientific™ DynaDrive™ S.U.B.
The use of single-use technologies (SUTs) and systems in bioprocessing enables many benefits, such as rapid product changeover, reduction or elimination of caustic waste from cleaning, and facility flexibility for activities like multi-product operations. Facility updates to match processes with new and emerging technologies are more straightforward with SUTs, allowing facilities to be deployed more quickly and modularly than traditional steel buildouts.
As bioprocesses intensify through larger volumes, culture processes, and cell line development, SUT facilities are increasingly becoming economically competitive with large steel buildouts. This is particularly the case with enabling technologies like the Thermo Scientific™ DynaDrive™ Single-Use Bioreactors (S.U.B.s), which have unique high-performance capabilities to support high-intensity cultures and scale-up from 50 L to 5,000 L in working volume.