Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Immunogenicity and Safety of Primary Fractional-dose Yellow Fever Vaccine in Autoimmune Rheumatic Diseases
Brazil faced a yellow feverYF outbreak in and vaccination was considered for autoimmune rheumatic disease patientsARD with low immune suppression due to YF high mortality Yellow feverYF is an infectious disease caused by a Flavivirus Flaviviridae family Severe cases may evolve to bleeding disorders
Microsimulation Based Quantitative Analysis of COVID-19 Management Strategies
Pandemic management requires reliable and efficient dynamical simulation to predict and control disease spreading The COVID SARSCoV pandemic is mitigated by several nonpharmaceutical interventions but it is hard to predict which of these are the most effective for a given population
A Simple Assay to Quantify Mycobacterial Lipid Antigen-specific T Cell Receptors in Human Tissues and Blood
T cell receptors TCRs encode the history of antigenic challenge within an individual and have the potential to serve as molecular markers of infection In addition to peptide antigens bound to highly polymorphic MHC molecules T cells have also evolved to recognize bacterial lipids when
Vaccine Equity: A fundamental imperative in the fight against COVID-19
On March WHO declared the outbreak of severe acute respiratory syndrome coronavirus SARSCoV a global pandemic Now almost years on COVID continues to cause widespread morbidity mortality and disruption both directly and indirectly on a global scale The speed at which multiple effective vaccines were developed is a remarkable
The role of memory in non-genetic inheritance and its impact on cancer treatment resistance
Intratumour heterogeneity is a leading cause of treatment failure and disease progression in cancer While genetic mutations have long been accepted as a primary mechanism of generating this heterogeneity the role of phenotypic plasticity is becoming increasingly apparent as a driver of intratumour heterogeneity
Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens
The rapid sensitive and specific detection of SARSCoV is critical in responding to the current COVID outbreak In this proofofconcept study we explored the potential of targeted mass spectrometry MS based proteomics for the detection of SARSCoV proteins in both research samples and clinical specimens
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies
Understanding SARSCoV evolution and host immunity is critical to control COVID pandemics At the core is an armsrace between SARSCoV antibody and angiotensinconverting enzyme ACE recognition a function of the viral protein spike Mutations in spike impacting
Probing T-cell response by sequence-based probabilistic modeling
With the increasing ability to use highthroughput nextgeneration sequencing to quantify the diversity of the human T cell receptor TCR repertoire the ability to use TCR sequences to infer antigenspecificity could greatly aid potential diagnostics and therapeutics
Novel EDGE encoding method enhances ability to identify genetic interactions
Assumptions are made about the genetic model of single nucleotide polymorphisms SNPs when choosing a traditional genetic encoding additive dominant and recessive Furthermore SNPs across the genome are unlikely to demonstrate identical genetic models However running SNPSNP interaction analyses with every combination
MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells
Mammalian cells release different types of vesicles collectively termed extracellular vesicles EVs EVs contain cellular microRNAs miRNAs with an apparent potential to deliver their miRNA cargo to recipient cells to affect the stability of individual mRNAs and the cells transcriptome
