Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Repositioning of Anti-dengue Compounds Against SARS-CoV-2 as Viral Polyprotein Processing Inhibitor
A therapy for COVID Coronavirus Disease caused by Severe Acute Respiratory Syndrome Coronavirus SARSCoV remains elusive due to the lack of an effective antiviral therapeutic molecule The SARSCoV main protease Mpro which plays a vital role in the viral life cycle
Transfer Learning for Non-image Data in Clinical Research: A Scoping Review
Transfer learning is a form of machine learning where a pretrained model trained on a specific task is reused as a starting point and tailored to another task in a different dataset While transfer learning has garnered considerable attention in medical image analysis its use for clinical nonimage data is not well studied Therefore the objective of...
Sequencing SARS-CoV-2 from Antigen Tests
Genomic surveillance empowers agile responses to SARSCoV by enabling scientists and public health analysts to issue recommendations aimed at slowing transmission prioritizing contact tracing and building a robust genomic sequencing surveillance strategy Since the start of the pandemic real time RTPCR diagnostic testing from upper
The Properties of Human Disease Mutations at Protein Interfaces
The assembly of proteins into complexes and their interactions with other biomolecules are often vital for their biological function While it is known that mutations at protein interfaces have a high potential to be damaging and cause human genetic disease there has been relatively
The Impact of the COVID-19 Pandemic on Scientific Research in the Life Sciences
The COVID outbreak has posed an unprecedented challenge to humanity and science On the one side public and private incentives have been put in place to promptly allocate resources toward research areas strictly related to the COVID emergency However research in many fields not directly related to the pandemic has been displaced In this paper we ass...
Itemization Difference of Patient-reported Outcome in Patients with Chronic Liver Disease
The itemization difference of patientreported outcome PRO in hepatitis patients with different etiologies remains elusive in Asia We aimed to assess the characteristics and the difference of healthrelated quality of life HRQoL in chronic hepatitis B CHB chronic hepatitis C CHC and nonalcoholic fatty liver disease NAFLD patients
Beyond Inclusion: Enacting Team Equity in Precision Medicine Research
To identify meanings of and challenges to enacting equitable diversification of genomics research and specifically precision medicine research PMR teams There have been resounding calls for increased workforce diversity WFD and greater inclusion of underrepresented researchers in genomics and academic science more broadly Growing awareness of syste...
Preparing for Patients with High-consequence Infectious Diseases: Example of a High-level Isolation Unit
Patients with highconsequence infectious diseases HCID are rare in Western Europe However highlevel isolation units HLIU must always be prepared for patient admission Case fatality rates of HCID can be reduced by providing optimal intensive care management We here describe a single centres preparation its embedding in the national context and the c...
Prediction of Clinical Trial Enrollment Rates
Clinical trials represent a critical milestone of translational and clinical sciences However poor recruitment to clinical trials has been a long standing problem affecting institutions all over the world One way to reduce the cost incurred by insufficient enrollment is to minimize initiating trials that are most likely to fall short of their enrol...
Persistence of SARS-CoV-2 total Immunoglobulins in a series of Convalescent Plasma and Blood Donors
The vast majority of COVID cases both symptomatic and asymptomatic develop immunity after COVID contagion Whether lasting differences exist between infection and vaccination boosted immunity is yet to be known The aim of this study was to determine how long total antiSARSCoV antibodies due to past infection persist in peripheral blood
