Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Potential synergistic activity of quercetin with antibiotics against multidrug-resistant clinical strains of Pseudomonas aeruginosa
Development of drug resistance in opportunistic pathogens is one of the major healthcare challenges associated with infection management Combination therapy has many advantages due to the simultaneous action of two drugs on two separate cellular targets However selection of the drugs should offer safety and synergistic interaction against most of t...
Global gene network exploration based on explainable artificial intelligence approach
In recent years personalized gene regulatory networks have received significant attention and interpretation of the multilayer networks has been a critical issue for a comprehensive understanding of gene regulatory systems Although several statistical and machine learning approaches have been developed and applied to reveal samplespecific
Evaluation of classification and forecasting methods on time series gene expression data
Time series gene expression data is widely used to study different dynamic biological processes Although gene expression datasets share many of the characteristics of time series data from other domains most of the analyses in this field do not fully leverage the timeordered nature of the data and focus on clustering the genes based
Relative expression of microRNAs, apoptosis, and ultrastructure anomalies induced by gold nanoparticles in Trachyderma hispida (Coleoptera: Tenebrionidae)
The extensive use of nanomaterials generates toxic effects on nontarget species and the ecosystem Although gold nanoparticles AuNPs are generally expected to be safe the recent study contains conflicting data regarding their cytotoxicity in the darkling beetles Trachyderma hispida
Whole blood transcriptome biomarkers of unruptured intracranial aneurysm
The rupture of an intracranial aneurysm IA causes devastating subarachnoid hemorrhages yet most IAs remain undiscovered until they rupture Recently we found an IA RNA expression signature of circulating neutrophils
The relationship between circulating lipids and breast cancer risk
A number of epidemiological and genetic studies have attempted to determine whether levels of circulating lipids are associated with risks of various cancers including breast cancer BC However it remains unclear whether a causal relationship exists between lipids and BC
Age at diagnosis, glycemic trajectories, and responses to oral glucose-lowering drugs in type 2 diabetes in Hong Kong
Lifetime glycemic exposure and its relationship with age at diagnosis in type diabetes TD are unknown Pharmacologic glycemic management strategies for youngonset TD age at diagnosis
Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years
Based on different genetic and environmental risk factors and histology it has been proposed that rheumatoid arthritis RA consists of types autoantibodypositive and autoantibodynegative RA However until now this remained hypothetical
Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections
There is disagreement about the level of asymptomatic severe acute respiratory syndrome coronavirus SARSCoV infection We conducted a living systematic review and metaanalysis to address three questions Amongst people who become infected with SARSCoV what proportion does not experience symptoms at all during their infection
Patterns of COVID-19 testing and mortality by race and ethnicity among United States veterans
There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of severe acute respiratory syndrome coronavirus SARSCoV infection and coronavirus disease COVID
