Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq
Long noncoding RNAs lncRNAs localize in the cell nucleus and influence gene expression through a variety of molecular mechanisms Chromatinenriched RNAs cheRNAs are a unique class of lncRNAs that are tightly bound to chromatin and putatively function
Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional Data
Abstract Introduction The molecular underpinnings of the dissociation of cognitive performance and neuropathological burden are poorly understood and there are currently no known genetic or epigenetic determinants of the dissociation Methods and findings Residual cognition was quantified by regressing out the effects of cerebral patholo...
Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine
Abstract Background Inflammatory breast cancer IBC is a rare aggressive form of breast cancer associated with HER amplification with high risk of metastasis and an estimated median survival of y We performed an openlabel singlearm phase II clinical trial ClinicalTrialsgov NCT to in
Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model
Abstract Background Novel drug regimens are needed for tuberculosis TB treatment New regimens aim to improve on characteristics such as duration efficacy and safety profile but no single regimen is likely to be ideal in all respects By linking these regimen characteristics to a novel regimens ability
Open For Collaboration: An Academic Platform For Drug Discovery And Development At Scilifelab
Abstract Swedish pharmaceutical industry and research Being a small country with only million inhabitants Sweden has a proud history of successful organic growth of its pharmaceutical industry with companies such as Kabi the first company to license Genentechs recombinant DNA technology later overtaken by Pharmacia subs
Simultaneous Analysis Of Aliskiren And Hydrochlorothiazide In Pharmaceutical Preparations And Spiked Human Plasma By HPTLC
Abstract A simple selective and precise method based on HPTLC has been developed for the simultaneous determination of aliskiren and hydrochlorothiazide in a fixeddose tablet formulation and human plasma The chromatography was performed on silica gel GF plates with a mobile phase consisting of methanolchloroform vv Densitometric analys
Advancing TB Drug Regimen Development Through Innovative Quantitative Translational Pharmacology Methods and Approaches
Summary The development of novel TB multidrug regimens that are more efficacious and of shorter induration requires a robust drug development pipeline Advances in quantitative modeling and simulation can be used to maximize the utility of patientlevel data from prior and contemporary clinical trials thus optimizing study design for antiTB regimens...
Relationships Between Mechanical Properties And Drug Release From Electrospun Fibers Of PCL And PLGA Blends
Abstract Electrospun nanofibers have the potential to achieve high drug loading and the ability to sustain drug release Mechanical properties of the drugincorporated fibers suggest the importance of drugpolymer interactions In this study we investigated the mechanical properties of electrospun polycaprolactone PCL and poly DLlacticcoglycolic
Adaptation Of Targeted Nanocarriers To Changing Requirements In Antimalarial Drug Delivery
Abstract The adaptation of existing antimalarial nanocarriers to new Plasmodium stages drugs targeting molecules or encapsulating structures is a strategy that can provide new nanotechnologybased costefficient therapies against malaria We have explored the modification of different liposome prototypes that had been developed in our group for the t...
Antimicrobial Drug Use In Primary Healthcare Clinics: A Retrospective Evaluation
Summary Objectives To examine the appropriateness of antibiotics prescribed for acute infection based on the Malaysian national antibiotic guidelines and the defined daily dose DDD system of the World Health Organization WHO This study also aimed to describe the factors influencing the drug use pattern
