Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Discrete Event Simulation Modelling For Dynamic Decision Making In Biopharmaceutical Manufacturing
Abstract With the increase in demand for biopharmaceutical products industries have realised the need to scale up their manufacturing from laboratorybased processes to financially viable production processes In this context biopharmaceutical manufacturers are increasingly using simulationbased approaches to gain transparency of their current produ...
Antitubercular Drugs For An Old Target: GSK693 As A Promising InhA Direct Inhibitor
Abstract Despite being one of the first antitubercular agents identified isoniazid INH is still the most prescribed drug for prophylaxis and tuberculosis TB treatment and together with rifampicin the pillars of current chemotherapy A high percentage of isoniazid resistance is linked to mutations in the prodrug activating enzyme KatG so the discove...
Targeting Blood-brain-barrier Transcytosis – Perspectives For Drug Delivery
Abstract Efficient transcytosis across the bloodbrainbarrier BBB is an important strategy for accessing drug targets within the central nervous system CNS Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low In order to expand current research...
Thin Films As An Emerging Platform For Drug Delivery
Abstract Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool Thin films have been identified as an alternative approach to conventional dosage forms The thin films are considered to be convenient to swallow selfadministrable and fast dissolving dosage form all of which makes it as a versati...
In Silico Product Design Of Pharmaceuticals
Abstract The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms As the number of possible dosage forms may scale toward infinity their uniqueness requires a versatile production platform and numerical simulation in order to be manufactured efficiently A mathematical description of these syst...
Changing Paradigms In Bioequivalence Trials Submitted To The Ema For Evaluation – A Clinical And Regulatory Perspective
Abstract Background The selection of a robust bioequivalence BE study designs for registering a generic product remains still a hard task This task is still challenging despite the fact that generic products are much needed by health care providers in economical terms Thus BE study designs could be a means to
Validated Spectrometric Determination Of Penciclovir And Entecavir In Bulk And In Pharmaceutical Preparations
Abstract Simple rapid and sensitive spectroscopic methods were developed and validated for the determination of antiviral agents namely penciclovir PCV and entecavir ETV The first method is based on measuring the native fluorescence of each of the cited drugs at its optimum excitation and emission wavelengths The fluorescence intensity was measure...
Validation Of A Liquid Chromatographic Method For The Pharmaceutical Quality Control Of Products Containing Elacridar
Abstract Many anticancer drugs have an impaired bioavailability and poor brain penetration because they are substrates to drug efflux pumps such as Pglycoprotein and Breast Cancer Resistance Protein Elacridar is a strong inhibitor of these two drug efflux pumps and therefore has great potential to improve oral absorption and brain penetration of m...
Challenges Of Glycosylation Analysis And Control: An Integrated Approach To Producing Optimal And Consistent Therapeutic Drugs
Abstract Glycosylation of therapeutic proteins has a profound impact on their safety and efficacy Many factors shape the glycosylation of biotherapeutics ranging from expression systems and cell culture processes to downstream purification strategies Various analytical technologies have been developed to address questions concerning different aspe...
Translational Medicine Guide Transforms Drug Development Processes: The Recent Merck Experience
Abstract Merck is implementing a questionbased Translational Medicine Guide TxM Guide beginning as early as lead optimization into its stagegate drug development process Initial experiences with the TxM Guide which is embedded into an integrated development plan tailored to each development program demonstrated opportunities to improve target unde...
