Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
The Promises Of Quantitative Systems Pharmacology Modelling For Drug Development
Abstract Recent growth in annual new therapeutic entity NTE approvals by the US Food and Drug Administration FDA suggests a positive trend in current research and development RD output Prior to this the cost of each NTE was considered to be rising exponentially with compound failure occurring mainly in clinical phases Quantitative Systems Pharma
Temporal Trends And Factors Associated With Cardiovascular Drug Development, 1990 To 2012
Summary Cardiovascular disease remains a leading cause of death but stakeholders have recently raised concerns about the pace of innovation and investment in developing new therapeutics Here the authors characterized temporal trends in cardiovascular research and development over the past decades and the likelihood of successful completion of pre...
Recreational Drug Use In The Oslo Nightlife Setting: Study Protocol For A Cross-Sectional Time Series Using Biological Markers, Self-Reported And Qualitative Data
Abstract Introduction Recreational drug use in the nightlife setting carries the risk of many negative consequences such as violence injuries aberrant driving and sexual risktaking The aim of this study is to investigate recreational drug use and user characteristics among people visiting licensed premises for example nightclubs and bars by using...
Review On Potential Phytocompounds In Drug Development For Parkinson Disease: A Pharmacoinformatic Approach
Abstract Parkinsons disease PD is caused by human physiological function and is ranked as the second most common neurodegenerative disorder One of the prominent therapies currently available for PD is the use of dopamine agonists which mimic the natural action of dopamine in the brain and stimulate dopamine receptors directly Currently available p...
Spectrophotometric And Spectroscopic Studies On Charge Transfer Complexes Of Antifungal Drug Clotrimazole
Abstract Clotrimazole CLZ is an imidazole derivative which is therapeutically used as an antifungal drug The routine control analysis of CLZ requires rapid reliable accurate and precise methods for the quantification of drug in its pharmaceutical formulations Spectrophotometric methods are presented for the determination of antifungal agent which...
Analytical Methods For Determination Of Terbinafine Hydrochloride In Pharmaceuticals And Biological Materials
Abstract Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of mycosessince It is highly effective in the treatment of determatomycoses The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynamic and pharmacokinetic studies Ever since i...
Renal Drug Transporters And Their Significance In Drug–drug Interactions
Abstract The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites Renal drug transporters which are primarily located in the renal proximal tubules play an important role in tubular secretion and reabsorption of drug molecules in the kidney Tubular secretion is characterized by high clearance capacities broad subs...
Effectiveness Of A Novel Cellular Therapy To Treat Multidrug-resistant Tuberculosis
Abstract Introduction We urgently need novel treatments for multidrugresistant tuberculosis MDRTB Autologous mesenchymal stromal cell MSC infusion is one such possibility due to its potential to repair damaged lung tissue and boost immune responses We aimed to assess the effectiveness of MSC to impro
Evaluation Of Ion Exchange Processes In Drug-eluting Embolization Beads By Use Of An Improved Flow-through Elution Method
Abstract An improved method for evaluating drug release behaviour of drugeluting embolization beads DEBs was developed utilizing an openloop flowthrough system in which the beads were packed into an occlusive mass within the system and extracted with a flowing elution medium over time Glass beads were introduced into the beads mass in order to ens...
Spectrophotometric determination of Ethionamide in Pharmaceuticals using Folin-Ciocalteu reagent and Iron (III)-Ferricyanide as Chromogenic Agents
Abstract Two simple and sensitive spectrophotometric methods are described for the determination of ethionamide ETM in pure drug and tablets The first method is based on the reduction of FolinCiocalteu FC reagent by ETM in sodium carbonate medium to form a blue coloured complex which was measured at nm Molybdenumtungsten blue method In the second...
