Research & Development
Developing New Vaccines
Developing New Vaccines
Edward Jenners work in developing the worlds first smallpox vaccine in the s demonstrated that it was possible to protect the general population from major threats to public health and vaccine development aimed at combating the major concerns of the day has continued ever since There have been many successes and vaccines are now available to immuni...
Enhancing Antibody-based Cancer Therapy
Antibody combinations and dual-targeting bispecific antibodies
The additive and synergistic therapeutic effects derived from combinations of cytotoxic agents support the notion that cancer a disease of multiple genetic alterations must be attacked on multiple fronts In the past decades a number of chemotherapy regimens have been developed These regimens are usually cocktails that comprise several cytotoxic age...
Early Formulation
Shortening the development timelines
The duration of drug development cycles is continuously being challenged by an increasingly competitive industrial environment The number of drug candidates intended for preclinical and clinical development has dramatically increased by using modern highthroughput technologies such as combinatorial chemistry and pharmacological screening However in...
Model Behaviour
After the completion of the human genome project now the main focus is shifting to the investigation of the relationship between human biology and disease by means of molecular biology cell biology and genetics To learn roles of diseaserelated human genes it becomes more important to understand not only their corresponding proteins own functions bu...
Adjuvant Systems
Next stage of rational vaccine design
Vaccine adjuvants compounds used to enhance a vaccine antigens ability to elicit a desired immune response have been known and used for over years to increase the immune response against a given antigen With the continued emergence of new diseases and the need to find ways to address remaining disease challenges new breakthroughs in immunology off...
Targeted Delivery
Photosensitiser conjugated gold nanoparticles
Photodynamic Therapy PDT a minimal invasive cancer treatment approach holds tremendous promise in particularly treating the local tumours It is based on the administration of a photosensitising compound also called photosensitiser and subsequent irradiation with light of an appropriate wavelength to produce Reactive Oxygen Species ROS The elevated...
Antibacterial Research
Bright future?
The accidental discovery of Penicillin by Sir Alexander Fleming in followed by its development for use as a medicine by Australian Nobel Laureate Howard Walter Florey ushered in the era of antibiotics the antibacterial drug discovery peaked after the middle of th century However after the introduction of streptogramin and quinolones in Table no...
