Research & Development
Sonication-Assisted Nanoencapsulation
The desired features of pharmaceutical drug delivery for intravenous administration their small size biodegradability high content of a drug in a final preparation prolonged circulation in the blood and the ability to target required areas are reasonably well met by liposomes microcapsules and nanoparticles for watersoluble drugs The development of...
Layer-by-Layer Micro and Nano Drug Encapsulation with Eolyelectrolytes Progress and challenges
Since layerbylayer LbL polyelectrolyte assembly was introduced in the s by G Decher Y Lvov H Mhwald and M Rubner it has found application in various fields that study and apply nanotechnology LbL nanoassembly is based on the sequential adsorption of positively and negatively charged polymers on a surface to form a nanothick film of coating The proc...
Improving Pharmaceutical R&D
Using Lean Sigma
Pele ChoiSing Chong The pharmaceutical industry now operates in a complex and dynamic global environment The pace of change is much faster and far less predictable than ever before To survive and prosper in todays business environment we need to
Drug Discovery in Academia
An evolving model
Over the past decade there has been increasing pressure on the pharmaceutical industry to increase economic efficiencies in drug discovery This has been driven by several factors including the increased costs of RD lower productivity patent expiration generic competition and the increasing difficulty in bringing new chemical entities to market T...
Target Deconvolution in the Post-genomic Era
While the growing demand for innovative medicines is creating increasing opportunities for the pharmaceutical industry it is exactly this industry that suffers from an expensive disease itself known by the name innovation deficit In fact while the FDA approved New Molecular Entities NMEs and biologics in a nearly steady decline since then has led...
Biosimilar Medicines
Understanding the challenges
Many of the blockbuster biological products that currently dominate the markets are coming to the end of their patent protection The opportunity to provide more affordable generic versions is now attracting the interest of both generic and researchbased pharmaceutical companies The development of generic biological medicines referred to as
Personalised Medicine & Drug Development
Biomarkers leading the way
Up to the last decade the pharmaceutical industry had followed a trialanderror approach to medicine by applying a drug to an entire patient population when treating a given disease As a result the overall drug efficacy in selected diseases was only around per cent Moreover adverse drug reactions were among the leading causes for hospitalisation an...
Getting to the Bone
Fighting skeletal cancer metastases with specific T-lymphocytest
The skeleton is one of the most common target organs of metastases in human cancer Depending on the site of origin of the primary cancer bone metastases are diagnosed in to per cent of the patients Although breast prostate and lung cancers most frequently metastasise to the bone or bone marrow up to per cent of melanoma patients also develop ske...
Personalised Medicine
Changing Business Model
It has become clear that pharmaceutical development in the first decades of this century will be dominated by the personalised medicine concept Personalised medicine encompasses the development and marketing of molecular tests which help to target the use of pharmaceuticals and biologicals in ways that maximise their effectiveness Of course lab tes...
Current Advances in Proteomics
The fact that more than per cent of pharmaceutical drugs act through proteins reflects the importance of proteins as targets for diagnosis and treatment of diseases omics disciplines were developed to discover new biomarkers for health and medicine Among these disciplines proteomics is directly involved in drug development because disease processe...
