Year of Publication: 2016
Author(s) : Mike S. Lee and Qin C. Ji
This book illustrates the interdisciplinary advances of mass spectrometry (MS) and its applications for protein analysis. It focuses on studies that have contributed to the rapid progress and development of protein therapeutics to meet challenging medical needs. It brings together the most current advances in the mass spectrometry technology and related method in protein analysis including a variety of applications and their impact on accelerating discovery and development of protein biotherapeutics.
Split into four sections the book covers Principles, Instrumentation, Technologies (MS of peptides and proteins, instrumentation in protein analysis, and Chip technology in mass spectrometry protein analysis); Mass spectrometry protein analysis in understanding mechanism and functions in living cells; Mass spectrometry protein analysis in support development of protein therapeutic drugs (qualitative and quantitative aspects, protein analysis in process and product development, and for PK and TK studies); and finally Emerging areas from drug monitoring to patient care including MS in the analysis of protein, peptide and lipid biomarkers, biomarker discovery, regulatory perspectives, and new technologies.