Pharma Manufacturing practices include all methods that are required to develop Pharma services. These practices provide minimum requirements that must and should be met by pharmaceutical companies in order to provide high-quality products that will pose no risk to the patients/consumers at large. Pharmaceutical contract manufacturing process involves Pharmaceutical machinery, drug manufacturers contracting a firm for finished products or components. It can be seen as a type of outsourcing. Organizations succeed by focusing on what they do best to their consumers, partners or outsourced vendors. Contract manufacturing seems to fit neatly into this scenario.

ADVANCES IN SPRAY DRYING FOR THE IMPROVED DELIVERY OF POORLY SOLUBLE DRUGS

In recent years there have been more and more publications featuring spray drying to improve the bioavailability of drugs Up to 70 per cent of pipeline drugs are poorly soluble so use of the process is expected to increase An overview of spray drying including the latest advances and future prospect..

CLINICAL MANUFACTURING ON TIME AND WITHIN BUDGET

In 2017 a record 46 submitted drugs received approval from the American regulatory agency FDA One of the reasons for this success is the reciprocal commitment between the sponsor and regulatory bodies to maintain a high quality of applications Both entities focus on reaching clinical end points as w..

Dissolution Prediction of Polymer-Coated Multiparticulates using In-Line Process Analytical Technology

The drug release rate of pharmaceutical drug products is critical for ensuring product effectiveness and patient safety This is controlled by the thickness of the coating layer applied to drug product particles This study demonstrated that inline particle size analysis is a viable method to predict ..

GEP MODELS FOR SCALING UP WET GRANULATION PROCESSES IN PLANETARY MIXERS

The utility of Gene Expression Programming GEP for predicting the endpoint of the granulation process in planetary mixers has been demonstrated GEP allows modelling the impeller power of the equipment as function of operation conditions and wet granule properties providing general experimental equat..

Multifunctional Nanoparticles for Check Point Inhibition and CAR-T Therapy

The recent advent of immunotherapies has transformed the landscape of cancer treatment In 2017 469 new clinical trials were reported on immunotherapy Although the effect of immunotherapy on cancer has been transformational they account for only a few percent of cancer patient population Thus nanopar..

USHERING IN THE FUTURE OF PHARMA

3D Printing opens the doors of possibility for pharmaceutical and medical device industries

3D manufacturing carves out a niche in the pharmaceutical industry While its hard to foresee the wholesale replacement of current tablet manufacturing processes 3D technology creates the opportunity for precise deposition of niche medications and personalise tablets This article will explore potenti..

Residence Time Distribution (RTD) Model

Novel applications to continuous pharmaceutical manufacturing

The Residence Time Distribution RTD is a fundamental chemical engineering concept By definition it is the probability distribution of time that solid or luid materials stay inside one or more unit operations in a continuous flow system It can be used to characterise the mixing and flow behaviour of ..

Drug Concentration Assurance of Continuous Tablet Manufacturing

Advanced process control strategy

In the pharmaceutical industry Real Time Release RTR can be facilitated by the development of a highly efficient control system The drug concentration in final tablet is one of the most critical quality attributes that must be assured before releasing the final product to the market Therefore a mult..

Pharmaceutical Crystallisation

Emerging process intensification technologies

Crystallisation is used extensively in the pharmaceutical industry for the separation and purification of chemical compounds Recently radically new technologies have been developed that allow for step improvements in the performance of pharmaceutical crystallisation This article provides a brief ove..

HPAPI Qualification Testing

Considerations in containment testing

Containment is critical in oral solid dose drug production particularly if it involves Highly Potent Active Pharmaceutical Ingredients HPAPI This article examines how containment valves and wireless monitoring can keep employees safe and improve manufacturing efficiency..