Manufacturing

Pharma Manufacturing practices include all methods that are required to develop Pharma services. These practices provide minimum requirements that must and should be met by pharmaceutical companies in order to provide high-quality products that will pose no risk to the patients/consumers at large. Pharmaceutical contract manufacturing process involves Pharmaceutical machinery, drug manufacturers contracting a firm for finished products or components. It can be seen as a type of outsourcing. Organizations succeed by focusing on what they do best to their consumers, partners or outsourced vendors. Contract manufacturing seems to fit neatly into this scenario.

Systematic Framework for Implementation of RTD-based Control System into Continuous Pharmaceutical Manufacturing Pilot-plant

Residence Time Distribution RTD is a probability distribution function that describes how long a fluid or powder element spends inside a given operation Currently the Continuous Manufacturing CM is evolving as a preferred platform for pharmaceutical products involving solid dosages forms Therefore the pharmaceutical industries are going through a p...

ADVANCES IN SPRAY DRYING FOR THE IMPROVED DELIVERY OF POORLY SOLUBLE DRUGS

Spray drying is an important unit operation first patented in Essentially the technique involves the pumping of a solution through a nozzle into a drying chamber where the solvent is rapidly removed by hot gas to yield a dry powder Over the past couple of decades research has become more sophisticated and publications citing enhanced formulation b...

CLINICAL MANUFACTURING ON TIME AND WITHIN BUDGET

The key to successfully developing and shepherding a drug to the approval stage and beyond lies in careful planning right from the start of development Any and all issues that may arise during the process should be considered during this planning phase For gaining competitive advantages it is crucial to make the right decisions early In this regard...

Dissolution Prediction of Polymer-Coated Multiparticulates using In-Line Process Analytical Technology

Process Analytical Technology PAT is a mechanism for measuring and controlling process performance parameters and Critical Quality Attributes CQAs with the goal of ensuring final product quality Comprehensive implementation of PAT can compensate for process variability within normal operating conditions to ensure process and product quality is mana...

GEP MODELS FOR SCALING UP WET GRANULATION PROCESSES IN PLANETARY MIXERS

Wet Granulation WG process is a critical step for the production of many pharmaceutical dosage forms During this stage a liquid usually water is combined with a blend of active ingredients and excipients to form homogeneous granules with suitable properties to further processing The establishment of the end point of the wet granulation process i...

Multifunctional Nanoparticles for Check Point Inhibition and CAR-T Therapy

Rational of Reprogramming TumourImmune System The important role of our immune system is to recognise the foreign substance from the healthy cells and eliminate the foreign object from the body while maintaining the normal cells unharmed To do this the body immune cells such as lymphocytes and monocytes utilise unique check point molecules which...

USHERING IN THE FUTURE OF PHARMA

3D Printing opens the doors of possibility for pharmaceutical and medical device industries

Pharmaceutical manufacturers and consumers alike can look forward to a rapid evolution in the way medicine is manufactured and brought to market New possibilities in D printing are opening doors for both pharmaceutical research and applications such as personalised drug dosing complex drug release profiles and even bio printing The implications are...

Residence Time Distribution (RTD) Model

Novel applications to continuous pharmaceutical manufacturing

The Residence Time Distributions RTD can be determined experimentally through the injection of a tracer material into the process in the form of a pulse or a step To achieve this the outlet tracer concentration is measured until the effects of the injection settle down A key aspect to be considered during the experimental determination of resid...

Drug Concentration Assurance of Continuous Tablet Manufacturing

Advanced process control strategy

Currently pharmaceutical companies are going through a paradigm shift from conventional batch to Continuous Manufacturing CM process integrated with advanced automation and control system In CM Real Time Release Testing RTRT can be facilitated by the development of a highly efficient control system that can monitor and correct process variables in...

Pharmaceutical Crystallisation

Emerging process intensification technologies

Solution crystallisation is the formation of a crystalline solid state from a homogeneous solution Different methods exist to create the driving force for crystal nucleation and growth Common crystallisation methods are based on strategies to lower the solubility eg via cooling or the addition of a socalled antisolvent or to increase the solute con...

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