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Research Insights

Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.

Association of Serum Biomarkers with Early Neurologic Improvement after Intravenous Thrombolysis in Ischemic Stroke

Early neurologic improvement ENI after intravenous thrombolysis is associated with favorable outcome but associated serum biomarkers were not fully determined We aimed to investigate the issue based on a prospective cohort

DNA Damage and Antioxidant Capacity in COPD Patients with and without Lung Cancer

Chronic obstructive pulmonary disease COPD is characterized by chronic inflammation of the lower airways and COPD patients show two to five times higher risk of lung cancer than smokers with normal lung function COPD is associated with increased oxidative stress which may cause DNA damage and lung carcinogenesis

A New Machine Learning Method for Cancer Mutation Analysis

It is complicated to identify cancercausing mutations The recurrence of a mutation in patients remains one of the most reliable features of mutation driver status However some mutations are more likely to happen than others for various reasons Different sequencing analysis

Repositioning of Anti-dengue Compounds Against SARS-CoV-2 as Viral Polyprotein Processing Inhibitor

A therapy for COVID Coronavirus Disease caused by Severe Acute Respiratory Syndrome Coronavirus SARSCoV remains elusive due to the lack of an effective antiviral therapeutic molecule The SARSCoV main protease Mpro which plays a vital role in the viral life cycle

Transfer Learning for Non-image Data in Clinical Research: A Scoping Review

Transfer learning is a form of machine learning where a pretrained model trained on a specific task is reused as a starting point and tailored to another task in a different dataset While transfer learning has garnered considerable attention in medical image analysis its use for clinical nonimage data is not well studied Therefore the objective of...

Sequencing SARS-CoV-2 from Antigen Tests

Genomic surveillance empowers agile responses to SARSCoV by enabling scientists and public health analysts to issue recommendations aimed at slowing transmission prioritizing contact tracing and building a robust genomic sequencing surveillance strategy Since the start of the pandemic real time RTPCR diagnostic testing from upper

The Properties of Human Disease Mutations at Protein Interfaces

The assembly of proteins into complexes and their interactions with other biomolecules are often vital for their biological function While it is known that mutations at protein interfaces have a high potential to be damaging and cause human genetic disease there has been relatively

The Impact of the COVID-19 Pandemic on Scientific Research in the Life Sciences

The COVID outbreak has posed an unprecedented challenge to humanity and science On the one side public and private incentives have been put in place to promptly allocate resources toward research areas strictly related to the COVID emergency However research in many fields not directly related to the pandemic has been displaced In this paper we ass...

Itemization Difference of Patient-reported Outcome in Patients with Chronic Liver Disease

The itemization difference of patientreported outcome PRO in hepatitis patients with different etiologies remains elusive in Asia We aimed to assess the characteristics and the difference of healthrelated quality of life HRQoL in chronic hepatitis B CHB chronic hepatitis C CHC and nonalcoholic fatty liver disease NAFLD patients

Beyond Inclusion: Enacting Team Equity in Precision Medicine Research

To identify meanings of and challenges to enacting equitable diversification of genomics research and specifically precision medicine research PMR teams There have been resounding calls for increased workforce diversity WFD and greater inclusion of underrepresented researchers in genomics and academic science more broadly Growing awareness of syste...

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