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Research Insights

Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.

Vaccine Equity: A fundamental imperative in the fight against COVID-19

On March WHO declared the outbreak of severe acute respiratory syndrome coronavirus SARSCoV a global pandemic Now almost years on COVID continues to cause widespread morbidity mortality and disruption both directly and indirectly on a global scale The speed at which multiple effective vaccines were developed is a remarkable

The role of memory in non-genetic inheritance and its impact on cancer treatment resistance

Intratumour heterogeneity is a leading cause of treatment failure and disease progression in cancer While genetic mutations have long been accepted as a primary mechanism of generating this heterogeneity the role of phenotypic plasticity is becoming increasingly apparent as a driver of intratumour heterogeneity

Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens

The rapid sensitive and specific detection of SARSCoV is critical in responding to the current COVID outbreak In this proofofconcept study we explored the potential of targeted mass spectrometry MS based proteomics for the detection of SARSCoV proteins in both research samples and clinical specimens

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies

Understanding SARSCoV evolution and host immunity is critical to control COVID pandemics At the core is an armsrace between SARSCoV antibody and angiotensinconverting enzyme ACE recognition a function of the viral protein spike Mutations in spike impacting

Probing T-cell response by sequence-based probabilistic modeling

With the increasing ability to use highthroughput nextgeneration sequencing to quantify the diversity of the human T cell receptor TCR repertoire the ability to use TCR sequences to infer antigenspecificity could greatly aid potential diagnostics and therapeutics

Novel EDGE encoding method enhances ability to identify genetic interactions

Assumptions are made about the genetic model of single nucleotide polymorphisms SNPs when choosing a traditional genetic encoding additive dominant and recessive Furthermore SNPs across the genome are unlikely to demonstrate identical genetic models However running SNPSNP interaction analyses with every combination

MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells

Mammalian cells release different types of vesicles collectively termed extracellular vesicles EVs EVs contain cellular microRNAs miRNAs with an apparent potential to deliver their miRNA cargo to recipient cells to affect the stability of individual mRNAs and the cells transcriptome

Machine learning and deep learning techniques to support clinical diagnosis of arboviral diseases: A systematic review

Neglected tropical diseases NTDs primarily affect the poorest populations often living in remote rural areas urban slums or conflict zones Arboviruses are a significant NTD category spread by mosquitoes Dengue Chikungunya and Zika are three arboviruses that affect a large proportion of the population in Latin and South America

High-throughput framework for genetic analyses of adverse drug reactions using electronic health records

Understanding the contribution of genetic variation to drug response can improve the delivery of precision medicine However genomewide association studies GWAS for drug response are uncommon and are often hindered by small sample sizes

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

COVID vaccines based on the Spike protein of SARSCoV have been developed that appear to be largely successful in stopping infection However therapeutics that can help manage the disease are still required until immunity has been achieved globally

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