Research Insights

Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.

A spectrum of verticality across genes

Lateral gene transfer LGT has impacted prokaryotic genome evolution yet the extent to which LGT compromises vertical evolution across individual genes and individual phyla is unknown as are the factors that govern LGT frequency across genes Estimating LGT frequency from tree comparisons is problematic when thousands of genomes

Oxidative stress antagonizes fluoroquinolone drug sensitivity via the SoxR-SUF Fe-S cluster homeostatic axis

The level of antibiotic resistance exhibited by bacteria can vary as a function of environmental conditions Here we report that phenazinemethosulfate PMS a redoxcycling compound RCC enhances resistance to fluoroquinolone FQ norfloxacin Genetic analysis showed that E coli adapts to PMS stress by making

Mathematical modeling of hepatitis C RNA replication, exosome secretion and virus release

Hepatitis C virus HCV causes acute hepatitis C and can lead to lifethreatening complications if it becomes chronic The HCV genome is a single plus strand of RNA Its intracellular replication is a spatiotemporally coordinated process of RNA translation upon cell infection RNA synthesis within a replication compartment and virus particle production

Cell death and biomass reduction in biofilms of multidrug resistant extended spectrum β-lactamase-producing uropathogenic Escherichia coli isolates by 1,8-cineole

Escherichia coli is the most frequent agent of urinary tract infections in humans The emergence of uropathogenic multidrugresistant MDR E coli strains that produce extended spectrum lactamases ESBL has created additional problems in providing adequate treatment of urinary tract infections We have previously reported the antimicrobial activity of ci...

A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

The global coronavirus disease COVID pandemic caused by severe acute respiratory syndrome coronavirus SARSCoV has led to unprecedented social and economic consequences The risk of morbidity and mortality due to COVID increases dramatically in the presence of coexisting medical conditions

Potential synergistic activity of quercetin with antibiotics against multidrug-resistant clinical strains of Pseudomonas aeruginosa

Development of drug resistance in opportunistic pathogens is one of the major healthcare challenges associated with infection management Combination therapy has many advantages due to the simultaneous action of two drugs on two separate cellular targets However selection of the drugs should offer safety and synergistic interaction against most of t...

Global gene network exploration based on explainable artificial intelligence approach

In recent years personalized gene regulatory networks have received significant attention and interpretation of the multilayer networks has been a critical issue for a comprehensive understanding of gene regulatory systems Although several statistical and machine learning approaches have been developed and applied to reveal samplespecific

Evaluation of classification and forecasting methods on time series gene expression data

Time series gene expression data is widely used to study different dynamic biological processes Although gene expression datasets share many of the characteristics of time series data from other domains most of the analyses in this field do not fully leverage the timeordered nature of the data and focus on clustering the genes based

Relative expression of microRNAs, apoptosis, and ultrastructure anomalies induced by gold nanoparticles in Trachyderma hispida (Coleoptera: Tenebrionidae)

The extensive use of nanomaterials generates toxic effects on nontarget species and the ecosystem Although gold nanoparticles AuNPs are generally expected to be safe the recent study contains conflicting data regarding their cytotoxicity in the darkling beetles Trachyderma hispida

Whole blood transcriptome biomarkers of unruptured intracranial aneurysm

The rupture of an intracranial aneurysm IA causes devastating subarachnoid hemorrhages yet most IAs remain undiscovered until they rupture Recently we found an IA RNA expression signature of circulating neutrophils

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