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Research Insights

Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.

Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium

Biopharmaceutical products BPs are widely used to treat autoimmune diseases but immunogenicity limits their efficacy for an important proportion of patients Our knowledge of patientrelated factors influencing the occurrence of antidrug antibodies ADAs is still limited

DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines

DNA supercoiling is essential for all living cells because it controls all processes involving DNA In bacteria global DNA supercoiling results from the opposing activities of topoisomerase I which relaxes DNA and DNA gyrase which compacts DNA These enzymes are widely conserved sharing amino acid identity between the closely related

BADAN-conjugated β-lactamases as biosensors for β-lactam antibiotic detection

Lactam antibiotic detection has significant implications in food safety control environmental monitoring and pharmacokinetics study Here we report the development of two BADANconjugated lactamases ECb and ECbNQ as sensitive biosensors for lactam antibiotic detection

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

The ataxia telangiectasia and Radrelated ATR protein kinase is a key regulator of the cellular response to DNA damage Due to increased amount of replication stress cancer cells heavily rely on ATR to complete DNA replication and cell cycle progression Thus ATR inhibition is an emerging target in cancer therapy

LPCAT1 enhances castration resistant prostate cancer progression via increased mRNA synthesis and PAF production

Our previously study shown that Lysophosphatidylcholine Acyltransferase LPCAT is overexpressed in castration resistant prostate cancer CRPC relative to primary prostate cancer PCa and androgen controls its expression via the Wnt signaling pathway While highly expressed in CRPC the role of LPCAT

A spectrum of verticality across genes

Lateral gene transfer LGT has impacted prokaryotic genome evolution yet the extent to which LGT compromises vertical evolution across individual genes and individual phyla is unknown as are the factors that govern LGT frequency across genes Estimating LGT frequency from tree comparisons is problematic when thousands of genomes

Oxidative stress antagonizes fluoroquinolone drug sensitivity via the SoxR-SUF Fe-S cluster homeostatic axis

The level of antibiotic resistance exhibited by bacteria can vary as a function of environmental conditions Here we report that phenazinemethosulfate PMS a redoxcycling compound RCC enhances resistance to fluoroquinolone FQ norfloxacin Genetic analysis showed that E coli adapts to PMS stress by making

Mathematical modeling of hepatitis C RNA replication, exosome secretion and virus release

Hepatitis C virus HCV causes acute hepatitis C and can lead to lifethreatening complications if it becomes chronic The HCV genome is a single plus strand of RNA Its intracellular replication is a spatiotemporally coordinated process of RNA translation upon cell infection RNA synthesis within a replication compartment and virus particle production

Cell death and biomass reduction in biofilms of multidrug resistant extended spectrum β-lactamase-producing uropathogenic Escherichia coli isolates by 1,8-cineole

Escherichia coli is the most frequent agent of urinary tract infections in humans The emergence of uropathogenic multidrugresistant MDR E coli strains that produce extended spectrum lactamases ESBL has created additional problems in providing adequate treatment of urinary tract infections We have previously reported the antimicrobial activity of ci...

A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

The global coronavirus disease COVID pandemic caused by severe acute respiratory syndrome coronavirus SARSCoV has led to unprecedented social and economic consequences The risk of morbidity and mortality due to COVID increases dramatically in the presence of coexisting medical conditions

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