Thermo Fisher Scientific "Pharma Extrusion On-Demand Webinar"

Amorphous solid dispersions (ASDs) are an established approach for improving the performance of poorly soluble drug compounds. However, selecting the right manufacturing technology can have a major impact on energy consumption, drug release, product quality, and overall process efficiency.

This on-demand webinar presents a live laboratory comparison of Hot Melt Extrusion (HME) and Spray Drying (SD) for ASD production. Explore experimental data across different API concentrations and see how the two technologies compare in terms of specific energy consumption and dissolution performance.

The presentation also highlights the role of rapid cooling and Chill Roll technology in preserving the amorphous form, along with practical benefits such as a small process footprint and thin-flake production that can support downstream processing.

Key Takeaways:

• Compare HME and Spray Drying: Understand the equipment, process approach, and performance differences between the two technologies.
• Reduce Energy Consumption: Discover how HME demonstrated up to 60× lower energy consumption compared with spray drying in the evaluated formulations.
• Improve Dissolution Performance: Explore celecoxib dissolution results showing faster API release and improved “parachute effect” with HME-produced material.
• Explore Rapid Cooling: Learn how Chill Roll technology can rapidly cool extrudates and help preserve the amorphous form, supporting drug stability and bioavailability.
• Optimize Downstream Processing: Understand how thin flakes and a compact process footprint can provide practical advantages for milling and subsequent processing.
• See Real Laboratory Data: Gain insights from a direct, side-by-side evaluation of HME and spray drying using pharmaceutical processing equipment.