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Merck Announces First-of-its Kind Filters for CHO & Downstream Filtration Applications

Merck announced Millistak+® HC Pro, the first of its kind high capacity, fully synthetic depth filters for non-treated Chinese Hamster Ovary (CHO) harvest clarification and downstream filtration applications.

Millistak+® HC Pro filter media provides a cleaner and more consistent depth filtration process compared with traditional diatomaceous earth (DE) and cellulose-based filtration processes.

The Millistak+® HC Pro portfolio provides as much as twice the filtration capacity versus commercial DE-based benchmarks.

It also provides customers improved consistency that will help them design a robust and controlled clarification process.

Merck offers recent advancements in the productivity of upstream cell culture processes with the help of naturally derived filters currently available.

Millistak+® HC Pro filters reduce naturally derived components from the clarification process as they are made with purely synthetic materials.

They offer increased productivity with lower flushing recommendations. The synthetic media shows higher levels of host cell protein (HCP) clearance compared with traditional depth filters.

Millistak+® HC Pro filters reduce Total Organic Carbon (TOC) extractables and pre-use flush volume recommendations by 50 percent.

The synthetic nature of the filter media eliminates beta glucans that interfere with limulus amoebocyte lysate testing for bacterial endotoxins.

Millistak+® HC Pro filters are available in the disposable pod format for ease of use, and exist in three media grades for primary and secondary clarification, as well as downstream filtration applications.

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