Better Wet Granulation: Development, Scale-up and Manufacture

By Tim Freeman, Freeman Technology

Wet granulation is a common unit operation in the pharmaceutical industry yet accurate endpoint detection remains a challenge. Here we examine the contribution that dynamic powder rheometry can make, highlighting its ability to detect the transition from wet mass to granulate with the required sensitivity. Quantification of this transition point, with a measure that is independent of process scale, accelerates development and scale-up and improves manufacture.

To know more, feel free to download the official factsheet.