This Pharma Magazine is the source for a plethora of unique Pharma articles. Several notable figures from top pharma organisations are featured in the R&D, Manufacturing and Clinical Trials sections, with their expert knowledge of the field.
A discussion of patient as a consumer should take into account the economic status of country to which he she belongs Economic status to a great extent affects the power of patients as consumers in those markets This is because the economic maturity of a country in many cases also defines its healthcare systemThere is no homogenous model of he...
If you had run into Mark Engel CEO and founder of Excel PharmaStudies at the recent China Pharmaceutical RD Summit at Shanghai you would realise that even the young biotech industry in Asia is not immune to the rapid globalisation of drug discovery and development Excel a leading CRO was started by a western businessman in China and serves custome...
In response to the st century challenges to the health sector WHO established an important global commission on Macroeconomics and Health One of the important conclusions of the commission report indicated that by the year the world could save up to million lives every year by scaling up access to existing health interventions to prevent or treat...
Open source model in the pharma industry is currently used by nonprofit organisations and governments to discover drugs for diseases neglected by industry It is hoped that the open source model can be suitably adapted by the pharma industry and used as a sustainable business model to discover costefficient drugs and to offer other tangible benefits...
The fact that more than per cent of pharmaceutical drugs act through proteins reflects the importance of proteins as targets for diagnosis and treatment of diseases omics disciplines were developed to discover new biomarkers for health and medicine Among these disciplines proteomics is directly involved in drug development because disease processe...
The skeleton is one of the most common target organs of metastases in human cancer Depending on the site of origin of the primary cancer bone metastases are diagnosed in to per cent of the patients Although breast prostate and lung cancers most frequently metastasise to the bone or bone marrow up to per cent of melanoma patients also develop ske...
While the growing demand for innovative medicines is creating increasing opportunities for the pharmaceutical industry it is exactly this industry that suffers from an expensive disease itself known by the name innovation deficit In fact while the FDA approved New Molecular Entities NMEs and biologics in a nearly steady decline since then has led...
Pele ChoiSing ChongThe pharmaceutical industry now operates in a complex and dynamic global environment The pace of change is much faster and far less predictable than ever before To survive and prosper in todays business environment we need to
The desired features of pharmaceutical drug delivery for intravenous administration their small size biodegradability high content of a drug in a final preparation prolonged circulation in the blood and the ability to target required areas are reasonably well met by liposomes microcapsules and nanoparticles for watersoluble drugs The development of...
Human diseases not only impair bodily structures and functions but they also threaten the health and wellbeing of humans Current research on diseases focusses mainly on the microbiological immunological and pathological aspects rather than on the biomechanics of the diseases which may have direct link to their pathophysiological outcomes In fact so...
Discovering and developing a new drug is a costly and timeconsuming process Recent reports suggest that it costs around US million pretax to bring a new drug to market One approach to improve the efficiency and lower the cost of this process is to use appropriate models and assays early in the discovery phase to identify candidates that are likely...
These days pharmaceutical development is increasingly becoming an area where high tech solutions exist for every difficulty encountered Genomic analyses and biomarkers are required for enrolment in an ever increasing proportion of studies Contract Research Organisations CROs have electronic files of potential investigators and patients for many dis...
Proteomics is an emerging field that is frequently used for clinical biomarker discovery For this article proteomics is defined as a mass spectrometrybased approach used to identify proteins The biomarker discovery process is distinct from biomarker validation or the development of a clinical test The development of a clinical biomarker incurs heav...
A biological measurement of the activity of a drug is perhaps the most critical step in the series of tests required for product release for both clinical trials as well as the market and plays an important role in the stability assessment of drug candidates All drugs require a clearly defined specification for release wherever possible this should...
Singleuse disposables have become a common name in the biomanufacturing industry world over All major companies related to equipment and filtration products are present in this domain They are increasing their presence by introducing more products in the disposable singleuse format Some of the wellknown benefits are Lower capital investments...
Upstream productivity in the biomanufacturing industry is not being matched by improvements downstream For processes such as packedbed chromatography that cannot be scaled up indefinitely the future is starting to look bleak Manufacturers around the world are approaching the limits of productivity and scalability and innovative downstream processin...
The words process control as related to Active Pharmaceutical Ingredients APIs production are interesting Process can mean anything from simple singlestep reactions to very complicated chemistry multistep processes and continuous processing while control implies some state of stability and knowledge of the process and process steps Upon closer exam...
Industry of today is generating large amount of data Data that comes from raw materials excipients media and the process Most processes consist of a series of operations steps and are also equipped with instrumentations collecting parameters as the process is in operation The chemometrical analysis of the numerous data collected from such processes...
Effective package management is an increasingly critical capability for pharmaceutical companies Pressure to maximise the potential of current product portfolios due to thin pipelines has now propelled several companies to enhance packaging to add more value to the consumer as well as to reduce Cost of Goods Sold COGS Better packaging brings benefi...
How different are the industryacademia relations in India compared with the US and European countriesIn India industryacademia interrelations are not very strong Both industry and academia are not taking necessary initiatives to strengthen the relations as they do not consider this as a priority issue On the contrary in the US and European coun...
What are the prospects for conducting clinical trials in ChinaThere are a number of driving factors that make China very attractive for conducting clinical trials People are already aware of most of these factorsrelatively inexpensive market in China its growth potential and reasonably easy access to patients Additionally there has been an incr...
