Better ways to handle tablets using IBCs

Shaun Baker ,  Pharma Sales Director, Matcon Ltd

The benefits of using IBCs for efficient and flexible materials handling are widely appreciated and applied in modern facilities. Handling tablets in larger, single containers offer significant benefits and could reduce manufacturing costs whilst improving production efficiency, quality and safety.

Still handling tablets in drums?

It is common to find Intermediate Bulk Containers (IBCs) being used for handling powders and granules in solid dosage manufacturing processes, from initial Dispensing through to Tablet Compression or Capsule Filling.  The benefits of using IBCs for efficient and flexible materials handling at this stage of the process are widely appreciated and applied in modern facilities.

However, when it comes to tablets, these are still traditionally handled in small containers such as drums, small kegs or boxes.

In this article Shaun Baker, Pharmaceutical Sales Director for Matcon Limited,considers the benefits and challenges of handling tablets in larger volumes and using IBCs.

What’s wrong with handling tablets in drums?

Having had the opportunity to visitmany different solid dosage manufacturing facilities around the world, Iregularly see tabletsbeing handled in drums or small containers.  Most often these are plastic drums with liners, used to collect tablets from the tablet presses, transport them from compression to coating and again from coating to primary packing (blister packing or bottle filling), sometimes via tablet inspection or tablet printing.

In some facilities, tablets have been stored and transported in drums for so long that the reason for using this method has been lost (“we have always done it this way”).  In other instances, I have been toldthat small containers – and particularly plastic drums – were selected due to thelow initial investment cost and the concern that larger containers would damage the tablets.

There are however a number of limitations associated with handling tablets in drums or small containers:

1.    Efficiency and Traceability:
a.    Many drums are required to hold a full batch of tablets – this is not LEAN, as large numbers of drums mean more movements and more manual operations.
b.    Slow and inefficient transfers – when processes are running slow or are stopped because of the way that the tablets are transferred, this directly impacts on the Overall Equipment Effectiveness (OEE) and the productivity of the facility as a whole.
c.    Challenges toinventory control and traceability – as the batch is split in to many small sub-lots.

2.    Health & Safety:
a.    Manual movement and lifting of the drums – handling all of these small containers means repetitive manual work and the risk of injuries to operators.
b.    Requirement for PPE to protect operator – manual handling and open drum connections expose operators to the tablets and make it necessary for operators to use PPE as a primary containment method.

3.    Quality/GMP risks:
a.    Open connections during drum filling/emptying – with a high risk of contamination and cross-contamination of the tablets.
b.    Manual scooping or tipping of drums – risk of tablet damage as tablet quality is dependent upon the operator handling them with care.

The advantages of thinking bigger…

If larger batches of tablets can be handled in a single container, then this would replace many drumsand have significant LEAN benefits:

•    Less containers required per batch
•    Reduced movements of tablet containers
•    Reduced number  of connections/disconnections
•    Less space required for storage of containers (when empty and also inter-process)
•    Reduced cleaning requirement

This is possible using Tablet IBCs, which enable tablet batches of up to 750Kg to be handled in a single container.

These benefits are at their greatest when the tablet handling batch size has been optimised to fit the process.  Requirements and variables differ from facility to facility, however the diagram below shows this optimisation concept applied to a 600Kg batch coating process.

In this example, a double-sided tablet press feeds to 2 x 1000L IBCs.  Each IBC will receive 600Kg of tablets, which represents a coating batch.  After compression, one of the IBCs will feed these tablets by gravity in to a 600Kg batch coater and then, following the coating process, the full batch of tablets will be emptied from the coater by gravity into another IBC and taken to packing.

As drums require multiple connections/disconnections and significant manual operations at each stage of the process, IBCs need only one connection and disconnection at each point.  There is no splitting or combining of the tablet batches, which makes for easy inventory control & product traceability.

In the next three sections we look at the specific use of IBCs for tablet handling at compression, batch coating and primary packing, focussing on the ways in which IBC systems can improve production efficiency, tablet quality and operator safety.

Collecting tablets from compression in IBCs

Collecting tablets in drums or small containers means that a complete, compressed batch needs up to 20 - 50 of these units.Each drum filling operation can involve the following activities:
•    Collect empty drums
•    Add liner
•    Connect the liner to the outlet of the tablet press
•    Monitor fill level of tablets and change drums when full
•    Close the liner
•    Place a lid
•    Print off a label and attach it to the drum
•    Place the drum on a pallet

Carrying out so many operations for 20 or more drums is a very timeconsuming and wasteful activity.  By collecting tablets in a Tablet IBC of a size that matches the next process step (e.g. coating), then the operating time is reduced considerably.

Of course, for this approach to be successful, the uncoated tablets must be loaded into the IBC without damage.  This requires a particular type of Tablet IBC such as the one illustrated.  This Tablet IBC has a polyethylene construction and aspecialtablet spiral to protect the fragile tablets during loading.


Collecting the tablets from tablet presses requires the tablets to be elevated – often via elevator/de-dusters – and then fed into the inlet of the IBC.

Connection with the IBC inlet can be open or closed depending upon the containment requirement.  In either case there is only the requirement for one IBC connection/disconnection per batch, as compared with drums where there may be many changeovers per batch.  The result is better protection to the operator (enhanced safety) and better protection to the product(quality/GMP).

Feeding to – and receiving from – batch tablet coaters using IBCs

The process of opening and tipping drums into a batch tablet coater is completely manual, time consuming and often hard work for operators!  There are health and safety risks associated with lifting and tilting heavy drums.

In addition, the way in which tablets are loaded in to the coater is fully operator dependent and, as such, there is a risk of tablet damage at this stage.