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Control and Prediction of Solid-State of Pharmaceuticals: Experimental and Computational Approaches

Control and Prediction of Solid-State of Pharmaceuticals: Experimental and Computational Approaches

Pages: 238

Publisher: Springer Publishers

Year of Publication: 2016

Author(s) : Rajni Miglani Bhardwaj

Book Description:

This thesis investigates a range of experimental and computational approaches for the discovery of solid forms. Furthermore, we gain, as readers, a better understanding of the key factors underpinning solid-structure and diversity. A major part of this thesis highlights experimental work carried out on two structurally very similar compounds. Another important section involves looking at the influence of small changes in structure and substituents on solid-structure and diversity using computational tools including crystal structure prediction, PIXEL calculations, Xpac, Mercury and statistical modeling tools.

In addition, the author presents a fast validated method for solid-state form screening using Raman microscopy on multi-well plates to explore the experimental crystallization space. This thesis illustrates an inexpensive, practical and accurate way to predict the crystallizability of organic compounds based on molecular structure alone, and additionally highlights the molecular factors that inhibit or promote crystallization.

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