Drug Delivery: An Integrated Clinical And Engineering Approach

Author(s) : Yitzhak Rosen, Pablo Gurman, Noel Elman

Book Description:

Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.

Features:

•    Emphasizes an integrated clinical and engineering approach.
•   Covers oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems.
•   Describes the latest in drug delivery for cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications.
•   Explores micro- and nanotechnology for drug delivery, including microneedle-mediated vaccines, microsponges, and nanoparticles as tracking systems.
•   Examines special clinical states requiring innovative drug delivery modifications.
•   Discusses methods for improved drug delivery in clinical settings.
•   Discusses FDA regulation of drug delivery systems and bioethical challenges involved in advancing drug delivery.

https://www.crcpress.com/Drug-Delivery-An-Integrated-Clinical-and-Engineering-Approach/Rosen-Gurman-Elman/p/book/9781466565944