Pharma Focus Asia

Alphamab Oncology Developed First-of-its-kind KN026 for the Treatment of Gastric Cancer

Alphamab Oncology had developed KN026, a first-of-its-kind HER2 bispecific antibody for the treatment of HER2-positive gastric cancer and gastroesophageal junction cancer. 

The unique characteristics of KN026, including its dual HER2 signal blockade and efficacy against medium or low HER2 expression and Trastuzumab-resistant cell lines, make it a promising therapeutic option. 

The ability of KN026 to demonstrate increased binding affinity and better tumour inhibition in HER2-positive tumour cell lines compared to Trastuzumab and Pertuzumab combination therapy further supports its potential as a groundbreaking treatment option. The inhibitory effect on tumour cells with medium or low HER2 expression and resistance to Trastuzumab expands the scope of patients who may benefit from this novel HER2 bispecific antibody.

Gastric cancer, especially HER2-positive gastric cancer, poses a substantial health burden globally, with China accounting for a significant portion of new cases and deaths. The overexpression of HER2 in a subset of gastric cancer patients is associated with aggressive tumour behaviour and poor prognosis, underscoring the importance of effective HER2-targeted therapies.

KN026 has received breakthrough treatment designation, leading to the initial anti-HER2 treatment for second-line gastric cancer, particularly in cases where HER2-targeted therapy has proven ineffective.
 

magazine-slider-image
magazine-slider-image
Cytiva - Supor Prime filtersMFA + MMA 2024CPHI China || PMEC China 2024Asia Healthcare Week 2024CPHI Korea 2024CHEMICAL INDONESIA 2024World Orphan Drug Congress Europe 2024INALAB 2024Thermo Fisher - Drug Discovery and the impact of mAbsAdvanced Therapies USA 2024ISPE Singapore Affiliate Conference & Exhibition 20242024 PDA Cell and Gene Pharmaceutical Products Conference 2024 PDA Aseptic Manufacturing Excellence Conference2024 PDA Aseptic Processing of Biopharmaceuticals Conference3rd World ADC Asia 2024