Pharma Focus Asia

Breakthrough Nanoneedle Technology Introduced for Cancer Treatment

The research conducted by the team from Monash University's Institute of Pharmaceutical Sciences (MIPS) and Deakin University's School of Medicine represents a groundbreaking advancement in the field of cancer immunotherapy, particularly in CAR-T cell therapy.

Scientists have pioneered a world-first method for introducing beneficial genetic material into white blood cells, potentially revolutionising treatment options for specific types of blood cancer.

The innovative approach addresses the challenges of CAR-T cell therapy, a cutting-edge treatment involving the genetic modification of a patient's own white blood cells (T cells) for targeted cancer cell attack. The current CAR-T cell therapy process is hindered by its complexity, slow pace, and high costs.

The research team has introduced a remarkable solution by utilising nano-needles, which are a staggering 100,000 times finer than a human hair, to deliver genetic material into T cells.

This breakthrough eliminates the need for inactive viral vectors, which are conventionally used to transport genetic material into cells but have been associated with costly treatment delays in CAR-T cell production.

The non-viral approach not only simplifies the process but also enhances safety by sidestepping viral vector-related concerns. Furthermore, the application of nanotechnology offers the possibility of conducting the entire procedure within a hospital setting.

This development addresses an urgent demand for a scalable, cost-effective, and streamlined CAR-T cell manufacturing process that does not rely on viral vectors. By harnessing nanotechnologies, the researchers are enabling the precise delivery of advanced non-viral therapeutics into primary human immune cells, which are difficult to transfect.

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