Pharma Focus Asia
KP - Choose our fully recyclable blister films

New Drug Development Workflow Designed for Extrusion-Based Drug Implant Production

The Thermo Scientific Pharma mini implant line, first end-to-end solution, is an automated, integrated system designed for continuous production of drug implants.

Drug formulation scientists can use the first commercially available, fully integrated solution for polymer-based drug implant development and production using Hot Melt Extrusion (HME) to meet growing demand for innovative drug delivery systems in the pharmaceutical industry.

Pharmaceutical manufacturers can get a complete end-to-end manufacturing line from a single supplier through new drug development workflow.

The Thermo Scientific Pharma mini implant line is built around the Thermo Scientific Pharma mini HME twin-screw micro compounder.

To enhance product quality, maximize operator safety and reduce the risk of contamination, Thermo Scientific Pharma mini implant provides drug developers, process manufacturing scientists and engineers with a continuous and fast production process.

This integrated production line is also designed to allow Contract Research and Manufacturing Organisations (CRO/CMO) to develop and optimise small-scale formulations before engaging in larger-scale production.

With a single subcutaneous injection, advanced drug implants can release a therapeutic substance that can provide patients with improved drug compliance, effective disease treatment or controlled hormonal regulation for weeks or even months.

This new automated implant line offers a hot melt extrusion solution designed to minimize formulation development time as pharmaceutical manufacturers are seeking fast, reliable solutions for continuous production of novel drug delivery systems.

The Thermo Scientific Pharma mini implant line incorporates a range of components in an innovative configuration. In addition to the Pharma mini HME micro compounder, components include:

•    A containment valve to add the Active Pharmaceutical Ingredient (API) and the polymer, designed to protect the operator from exposure to the API and preventing contamination of the API
•    A gravimetric feeder to deliver the API/polymer into the micro compounder for heating and mixing before the melt is extruded through a die that creates a continuous filament
•    New bi-axial lasers that measure the thickness or diameter of the filament to adjust the stretching or ‘take-off’ speed of the conveyor belt and
•    Proprietary equipment that cuts the filament to a desired implant length while maintaining ‘roundness’ without deforming the implant shape.

Latest Issue
Get instant
access to our latest e-book
THERMOFISHER SEACertara - Is your drug program on trackMasterControl - Manufacturing demoMasterControl - QMS demoThermo Fisher Scientific - Rapid Mycoplasma TestingThermoFisher Scientific - Save costs on your downstream process todayThermo Fisher Scientific - PeptonesMerck - Mobius® products5th Annual Pharma Manufacturing and Automation Convention 2023DUPHAT 202410TH ANNUAL GCC PHARMACY CONGRESS 202314th Annual Emirates Cardiac Society Conference 2023The International Hand & Wrist Congress 2023LabAsia 2023Pharma & Patient USA 2023Pharma Customer Engagement Europe 2023CHEMICAL INDONESIA 2024INALAB 2024