Pharma Focus Asia

MHC Class II UltimersT from ProImmune

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MHC Class II Ultimers™ ProImmune manufactures MHC Class II Ultimers™, a multimer technology with a superior peptide-linked planar design and optimized fluorochrome for immunologists who wish to detect and quantitate CD4+ antigen-specific T cells.

ProImmune delivers custom Class II Ultimers™ quickly, in weeks rather than months, with stringent quality control and low batch-to-batch variability. It is a fully compatible technology; the staining procedure is substantially the same as that for other MHC tetramers. The staining protocols for the use of Class II Ultimers™ are essentially the same as those for Class II tetramers.

Consistent with our Pro5® MHC Pentamers, Class II Ultimers™ are available as custom made and off the shelf products. Similar to Class I Pentamers, custom Class II Ultimers™ are available in 6 weeks. ProImmune's Class II Ultimer™ technology is affordable and prices are comparable with the existing Pentamer technology.
 

Enhanced Conformation and Sterics

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Analogous with MHC Pentamers, MHC Class II Ultimers™ are aligned in a planar configuration, optimized for best access of the T Cell Receptors (TCRs) on the cell surface to the MHC binding groove. Class II Ultimers™ are linked to a core structure through their peptides, which means that each MHC molecule can independently align with its complementary TCR, improving the binding characteristics. In contrast, in a standard tetramer all MHC molecules point away from the central streptavidin core and therefore their peptide binding grooves do not face in the same direction.
 

Fluorescent Label

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The labeling technology for Class II Ultimers™ has been optimized in order to achieve the best combination of signal strength (brightness) and low background (non-specific) staining. Class II Ultimers™ are available labeled with R-PE and APC.

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