Pharma Focus Asia

UC San Diego Health Introduced Novel Therapy for Melanoma

UC San Diego Health has unveiled a pioneering immunotherapy treatment for metastatic melanoma, heralding a breakthrough in cancer care. 

This novel approach utilises personalised cellular therapy derived from tumour infiltrating lymphocytes (TIL), making it the first of its kind for solid tumour therapy.

This cellular immunotherapy presents a robust solution for patients grappling with advanced melanoma that has proven resistant to conventional therapies, leaving them with limited treatment alternatives.

The procedure for TIL therapy, featuring lifileucel (AMTAGVI), commences with the extraction and isolation of the patient's specialised cancer-fighting white blood cells—either lymphocytes or T-cells—from the surgically excised tumour tissue.

These T-cells undergo isolation, expansion, and stimulation to bolster their capacity to identify, infiltrate, and combat cancerous cells. Following this enhancement, the augmented army of TIL cells is reintroduced into the patient through infusion.

Clinical trials of TIL therapy have yielded promising treatment outcomes, showcasing superior efficacy compared to alternative options following melanoma progression on standard frontline therapy.

This cellular therapy not only holds the promise of inducing remission in select patients but also augments the array of available treatment modalities for individuals confronting the spread of cancer cells beyond their originating site.

The introduction of cellular therapy represents a significant stride forward in melanoma treatment, offering renewed hope and expanded therapeutic options for patients confronting the challenges of advanced-stage disease.

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