Pharma Focus Asia

UChicago Medicine Discovered First-of-its-kind Resmetirom Drug for Metabolic Liver Disease

The University of Chicago Medicine has unveiled a groundbreaking drug designed to tackle advanced metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease (NAFLD).

Resmetirom marks the inaugural medication addressing metabolic dysfunction-associated steatohepatitis (MASH), an escalated phase of MASLD characterised by liver inflammation and fibrosis, which involves scarring.

For individuals suffering from conditions such as metabolic dysfunction-associated steatotic liver disease (MASLD) or its more advanced stage, metabolic dysfunction-associated steatohepatitis (MASH), resmetirom offers new hope.

These diseases are characterised by liver inflammation and fibrosis, which can lead to severe complications such as liver failure, cancer, and the need for transplantation. Resmetirom, as the first medication demonstrated to address fibrosis, presents a significant breakthrough in the field of liver disease treatment.

Historically, there has been a lack of effective treatments capable of reversing fibrosis, the underlying damage that contributes to the progression of these conditions. By targeting fibrosis, resmetirom not only addresses a critical aspect of liver disease pathogenesis but also holds the potential to mitigate the cascade of downstream complications.

With an estimated 25 million people in the United States affected by metabolic liver diseases, the introduction of resmetirom has far-reaching implications. It offers the prospect of improving outcomes and quality of life for a significant portion of the population burdened by these conditions.

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