Pharma Focus Asia

UVA Health Discovered New Vorasidenib Drug for Brain Tumour

UVA Health's research has unveiled the potential of vorasidenib in treating grade 2 IDH-mutant gliomas. This discovery marks a significant stride in identifying a promising drug that will positively impact patients grappling with these specific tumours.

In the INDIGO clinical trial, vorasidenib demonstrated promising results by significantly slowing tumour growth. The drug notably extended the average duration until tumour progression, elevating it from 11.1 months to over 27 months.

Doctors are often lead to adapt a watch and wait" strategy due to limited treatment options when managing brain tumours, delaying intervention until the tumour shows progression.

Vorasidenib presents a groundbreaking first early treatment for this cancer, offering patients a crucial new option that holds the potential to prolong their lives.

The hallenging nature of current standard therapies like radiation and chemotherapy, which often come with significant short- and long-term side effects, having a well-tolerated treatment option like vorasidenib will significantly improve the quality of life while effectively combating these tumours.

About 2,500 Americans, with a median age of just 40, receive a diagnosis of grade 2 IDH-mutant gliomas annually. These tumours profoundly impact cognitive abilities, often disrupting employment and daily functioning. Despite available treatments, these tumours commonly develop resistance, leading to fatal outcomes for most patients.

The challenges posed by these tumours emphasise the critical need for effective therapies like vorasidenib to enhance patient prognosis and well-being.

If approved by the federal Food and Drug Administration, this drug would represent the pioneering targeted therapy specifically designed for low-grade gliomas.

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