Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Multitask Learning of a Biophysically-detailed Neuron Model
The human brain operates at multiple levels from molecules to circuits and understanding these complex processes requires integrated research efforts Simulating biophysicallydetailed neuron models is a computationally expensive but effective method for studying local neural circuits Recent innovations have shown that artificial neural networks ANNs...
mRNA and circRNA Mislocalization to Synapses are Key Features of Alzheimer’s Disease
Proper transport of RNAs to synapses is essential for localized translation of proteins in response to synaptic signals and synaptic plasticity Alzheimers disease AD is a neurodegenerative disease characterized by accumulation of amyloid aggregates and hyperphosphorylated tau neurofibrillary tangles followed by widespread synapse loss To understand
An Integrative Approach to Protein Sequence Design Through Multiobjective Optimization
With recent methodological advances in the field of computational protein design in particular those based on deep learning there is an increasing need for frameworks that allow for coherent direct integration of different models and objective functions into the generative design process Here we demonstrate how evolutionary multiobjective
An mRNA Vaccine for Pancreatic Cancer Designed by Applying in Silico Immunoinformatics and Reverse Vaccinology Approaches
Pancreatic ductal adenocarcinoma PDAC which constitutes of pancreatic cancer PC is the fourth most prevalent cause of cancerrelated mortality globally A study suggests that by the number of deaths in the US from PC will surpass that from breast
Compositionally Aware Estimation of Cross-correlations for Microbiome Data
Sequencing data are ubiquitous in modern biology For example RNAseq data have been used to identify genes associated with clinical outcomes of cancer patients
A Cell Competition System with One Gene Expression from a Single-copy Gene in One Cell
Cell competition CC is a biological mechanism highly conserved from Drosophila to vertebrates and results in the elimination of less fit cells by their more fit neighbors
Analysis of Prognostic Factors in Critically Ill Patients with COVID-19
The Coronavirus Disease COVID caused by the SARSCoV virus emerged in late and rapidly evolved into a global pandemic impacting healthcare systems and economies worldwide
Targeting of Nanoparticles to the Cerebral Vasculature after Traumatic Brain Injury
Traumatic brain injury results in hospitalizations and deaths in the US each year annually While there have been multiple TBI clinical treatment trials todate none have been successful One major challenge
Identification of Circulating miRNAs as Fracture-related Biomarkers
Fracture nonunions affect many patients leading to functional and psychosocial disability Several risk factors have been described and include biological surgical and mechanical factors However none of them are able to determine
Parametric Analysis of SARS-CoV-2 Dose-response Models in Transportation Scenarios
There has been significant concern regarding the spread of SARSCoV on transportation systems The earliest superspreading events were associated with transportation on cruise ships Multiple incidents
