Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
An Agent-based Model of Metabolic Signaling Oscillations in Bacillus Subtilis Biofilms
Microbes of nearly every species can form biofilms communities of cells bound together by a selfproduced matrix It is not understood how variation
A Meta-contrastive Learning Approach for Clinical Drug-drug Interaction Extraction From Biomedical Literature
Drugdrug interactions DDIs are a significant source of adverse drug events and pose critical challenges to patient safety and clinical decisionmaking Extracting DDIs from biomedical literature plays an essential role in pharmacovigilance yet remains difficult due to data sparsity and high annotation costs
The Shape of Waning Vaccinal Immunity: Implications For Control
The COVID pandemic and current uncertainties about HN influenza underscore the importance of vaccination for both community immunity and to prevent pathogen invasion While the duration of a fullyimmune period
Enhancing Drug Repositioning: A Multi-class Ensemble Model for Drug-target Interaction Prediction with Action Type Categorization
Accurate prediction of drugtarget interactions DTIs is critical for accelerating drug repositioning and reducing the cost of pharmaceutical development Most existing studies frame DTI prediction as a binary task
Designing Influenza Virus-derived Cell-penetrating Peptides for Antigen Delivery: Integrating Uptake Efficiency, Safety, and Receptor Targeting
Successful antigen delivery is of paramount importance for successful vaccination Cellpenetrating peptides CPPs offer a highly effective means of delivering antigens nucleic acids and other drug compounds to cells
Drug-related Stigma Among People Who Inject Drugs – Development and Validation of the Drug Use Stigma Scale (DUSS)
Drug use is a highly stigmatized behavior and drugrelated stigma is a key driver of behavioral risk lower health care utilization and associated adverse health outcomes among people who inject drugs PWID
MiRScore: A Rapid and Precise MicroRNA Validation Tool
MicroRNAs miRNAs are small nonproteincoding RNAs that regulate gene expression in many eukaryotes Nextgeneration sequencing of small RNAs small RNAseq is central to the discovery and annotation of miRNAs
Drug-disease Networks and Drug Repurposing
Repurposing existing drugs to treat new diseases is a costeffective alternative to de novo drug development but there are millions of potential drugdisease combinations to be considered with only a small fraction being viable
A Curriculum Learning Approach to Training Antibody Language Models
There is growing interest in pretraining antibody language models AbLMs with a mixture of unpaired and natively paired sequences seeking to combine the proven benefits of training with natively paired sequences
Uncovering Key Biomarkers, Potential Therapeutic Targets and Development of Deep Learning Model in Heart Failure
Heart failure HF represents a significant public health concern characterized by elevated rates of mortality and morbidity Recent advancements in gene sequencing technologies have led
