Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
MiRScore: A Rapid and Precise MicroRNA Validation Tool
MicroRNAs miRNAs are small nonproteincoding RNAs that regulate gene expression in many eukaryotes Nextgeneration sequencing of small RNAs small RNAseq is central to the discovery and annotation of miRNAs
Drug-disease Networks and Drug Repurposing
Repurposing existing drugs to treat new diseases is a costeffective alternative to de novo drug development but there are millions of potential drugdisease combinations to be considered with only a small fraction being viable
A Curriculum Learning Approach to Training Antibody Language Models
There is growing interest in pretraining antibody language models AbLMs with a mixture of unpaired and natively paired sequences seeking to combine the proven benefits of training with natively paired sequences
Uncovering Key Biomarkers, Potential Therapeutic Targets and Development of Deep Learning Model in Heart Failure
Heart failure HF represents a significant public health concern characterized by elevated rates of mortality and morbidity Recent advancements in gene sequencing technologies have led
Understanding and Mitigating the Impact of Ambient mRNA Contamination in Single-cell RNA-sequencing Analysis
Dropletbased singlecell RNA sequencing scRNAseq frequently encounters significant challenges from contamination of cellfree mRNAs known as ambient mRNAs which can substantially distort singlecell transcriptome
Drug-induced Vitiligo: A real-world Pharmacovigilance Analysis of the FAERS Database
In recent years with the expanding use of novel therapeutics such as immune checkpoint inhibitors and monoclonal antibodies reports of druginduced vitiligo have been increasing This study aimed
A Cytotoxic Peptide-drug Conjugate for Tumor-specific Delivery of Co-injected Molecules
An ideal cancer therapy enhances antitumor effects while minimizing side effects iRGD a noncytotoxic peptide that activates a tumorspecific molecular transport machinery promotes the penetration of coinjected
Drug-induced Liver Injury Prediction Based on Graph Convolutional Networks and Toxicogenomics
Druginduced liver injury is a leading cause of high attrition rates for both candidate drugs and marketed medications Previous in silico models may not effectively utilize biological drug property information and often lack robust model validation In this study
Immune Signatures of SARS-CoV-2 Infection Resolution in Human Lung Tissues
While human autopsy samples have provided insights into pulmonary immune mechanisms associated with severe viral respiratory diseases the mechanisms that contribute to a clinically favorable resolution of viral respiratory infections remain unclear
Genetic Association of Lipids Characteristics and Lipid Lowering Drug Target Genes with Sepsis
Sepsis is a severe systemic infection that can result in organ dysfunction and mortality Dyslipidemia emerges as a key player in the intricate web of sepsis pathogenesis Yet the causal relationship between
