Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Machine Learning–based New Classification for Immune Infiltration of Gliomas
Glioma is a highly heterogeneous and poorly immunogenic malignant tumor with limited efficacy of immunotherapy The characteristics of the immunosuppressive tumor microenvironment TME are one of the important factors hindering the effectiveness of immunotherapy Therefore this study aims to reveal the immune microenvironment IME characteristics of gl...
GenerRNA: A Generative Pre-trained Language Model for de novo RNA Design
The design of RNA plays a crucial role in developing RNA vaccines nucleic acid therapeutics and innovative biotechnological tools However existing techniques frequently lack versatility across various tasks and are dependent on predefined secondary structure or other prior knowledge
SARS-CoV2 mRNA Vaccine Intravenous Administration Induces Myocarditis in Chronic Inflammation
The current COVID mRNA vaccines were developed and applied for pandemicemergent conditions These vaccines use a small piece of the viruss genetic material mRNA to stimulate an immune response against COVID
Prioritizing Disease-related Rare Variants by Integrating Gene Expression Data
Rare variants comprising the vast majority of human genetic variations are likely to have more deleterious impact in the context of human diseases compared to common variants Here we present carrier statistic a statistical framework to prioritize diseaserelated rare variants
Comparative Genomic Landscape of Lower-grade Glioma and Glioblastoma
Biomarkers for classifying and grading gliomas have been extensively explored whereas populations in public databases were mostly WesternEuropean Based on public databases cannot accurately represent Chinese population To identify molecular characteristics
Emergence of Crucial Evidence Catalyzing the Origin Tracing of SARS-CoV-2
Since the emergence of severe acute respiratory syndrome coronavirus SARSCoV its genetic and geographical origins remain unclear resulting in suspicions about its natural origin In one of our previous studies we reported the presence of a furin cleavage site
Feasibility of the Inhibitor Development for Cancer: A Systematic Approach for Drug Design
The traditional Chinese medicine TCM bupleurumgingerlicorice formula presents significant anticancer effects but its active ingredients and inhibitory mechanism remain unclear In this work the core effective ingredient quercetin and its signal transducer and activator of transcription
Improving Population Scale Statistical Phasing with Whole-genome Sequencing Data
Haplotype estimation or phasing has gained significant traction in largescale projects due to its valuable contributions to population genetics variant analysis and the creation of reference panels for imputation and phasing of new samples To scale with the growing number of samples haplotype estimation methods designed for population scale rely on...
Multitask Learning of a Biophysically-detailed Neuron Model
The human brain operates at multiple levels from molecules to circuits and understanding these complex processes requires integrated research efforts Simulating biophysicallydetailed neuron models is a computationally expensive but effective method for studying local neural circuits Recent innovations have shown that artificial neural networks ANNs...
mRNA and circRNA Mislocalization to Synapses are Key Features of Alzheimer’s Disease
Proper transport of RNAs to synapses is essential for localized translation of proteins in response to synaptic signals and synaptic plasticity Alzheimers disease AD is a neurodegenerative disease characterized by accumulation of amyloid aggregates and hyperphosphorylated tau neurofibrillary tangles followed by widespread synapse loss To understand
