Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Comparative Genomic Landscape of Lower-grade Glioma and Glioblastoma
Biomarkers for classifying and grading gliomas have been extensively explored whereas populations in public databases were mostly WesternEuropean Based on public databases cannot accurately represent Chinese population To identify molecular characteristics
Emergence of Crucial Evidence Catalyzing the Origin Tracing of SARS-CoV-2
Since the emergence of severe acute respiratory syndrome coronavirus SARSCoV its genetic and geographical origins remain unclear resulting in suspicions about its natural origin In one of our previous studies we reported the presence of a furin cleavage site
Feasibility of the Inhibitor Development for Cancer: A Systematic Approach for Drug Design
The traditional Chinese medicine TCM bupleurumgingerlicorice formula presents significant anticancer effects but its active ingredients and inhibitory mechanism remain unclear In this work the core effective ingredient quercetin and its signal transducer and activator of transcription
Improving Population Scale Statistical Phasing with Whole-genome Sequencing Data
Haplotype estimation or phasing has gained significant traction in largescale projects due to its valuable contributions to population genetics variant analysis and the creation of reference panels for imputation and phasing of new samples To scale with the growing number of samples haplotype estimation methods designed for population scale rely on...
Multitask Learning of a Biophysically-detailed Neuron Model
The human brain operates at multiple levels from molecules to circuits and understanding these complex processes requires integrated research efforts Simulating biophysicallydetailed neuron models is a computationally expensive but effective method for studying local neural circuits Recent innovations have shown that artificial neural networks ANNs...
mRNA and circRNA Mislocalization to Synapses are Key Features of Alzheimer’s Disease
Proper transport of RNAs to synapses is essential for localized translation of proteins in response to synaptic signals and synaptic plasticity Alzheimers disease AD is a neurodegenerative disease characterized by accumulation of amyloid aggregates and hyperphosphorylated tau neurofibrillary tangles followed by widespread synapse loss To understand
An Integrative Approach to Protein Sequence Design Through Multiobjective Optimization
With recent methodological advances in the field of computational protein design in particular those based on deep learning there is an increasing need for frameworks that allow for coherent direct integration of different models and objective functions into the generative design process Here we demonstrate how evolutionary multiobjective
An mRNA Vaccine for Pancreatic Cancer Designed by Applying in Silico Immunoinformatics and Reverse Vaccinology Approaches
Pancreatic ductal adenocarcinoma PDAC which constitutes of pancreatic cancer PC is the fourth most prevalent cause of cancerrelated mortality globally A study suggests that by the number of deaths in the US from PC will surpass that from breast
Compositionally Aware Estimation of Cross-correlations for Microbiome Data
Sequencing data are ubiquitous in modern biology For example RNAseq data have been used to identify genes associated with clinical outcomes of cancer patients
A Cell Competition System with One Gene Expression from a Single-copy Gene in One Cell
Cell competition CC is a biological mechanism highly conserved from Drosophila to vertebrates and results in the elimination of less fit cells by their more fit neighbors
