Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Immune Signatures of SARS-CoV-2 Infection Resolution in Human Lung Tissues
While human autopsy samples have provided insights into pulmonary immune mechanisms associated with severe viral respiratory diseases the mechanisms that contribute to a clinically favorable resolution of viral respiratory infections remain unclear
Genetic Association of Lipids Characteristics and Lipid Lowering Drug Target Genes with Sepsis
Sepsis is a severe systemic infection that can result in organ dysfunction and mortality Dyslipidemia emerges as a key player in the intricate web of sepsis pathogenesis Yet the causal relationship between
Characterization of Multi-targeted Insulin-mimetic Antidiabetic Peptides Using in Silico Approaches
Diabetes is a metabolic disease that can affect people at any age Despite being one of the leading causes of death the treatment of diabetes is extremely difficult For the treatment of diabetes mellitus various
Novel Insights into Post-myocardial Infarction Cardiac Remodeling Through Algorithmic Detection of Cell-type Composition Shifts
Interpreting bulk RNA sequencing from heterogeneous tissues like the postmyocardial infarction MI heart is confounded by dynamic changes in celltype composition To address this we developed a computational approach
Phenotype to Genotype: A New and Rapid Approach Using Whole-genome Sequencing
Forward genetic screening is a powerful approach to assign functions to genes and can be used to elucidate the many genes whose functions remain unknown A key step in forward genetic screening is mapping
Single-cell Mutational Burden Distributions in Birth–death Processes
Genetic mutations are footprints of cancer evolution and reveal critical dynamic parameters of tumour growth which otherwise are hard to measure in vivo
AI-first Structural Identification of Pathogenic Protein Target Interfaces
The risk of pandemics is increasing as global population growth and interconnectedness accelerate Understanding the structural basis of proteinprotein interactions between pathogens and hosts is critical
A Mathematical Framework for the Quantitative Analysis of Genetic Buffering
Genetic buffering plays a pivotal role in orchestrating the relationship between genotype and phenotype in outbred populations While highthroughput screens have identified many instances of genetic buffering
The Potential Global Health Impact and Cost-effectiveness of Next-generation Influenza Vaccines: A Modelling Analysis
Nextgeneration influenza vaccines NGIVs are in development and have the potential to achieve substantial reductions in influenza burden with resulting widespread health and economic benefits
Biomarkers of mRNA Vaccine Efficacy Derived from Mechanistic Modeling of Tumor-immune Interactions
The success of mRNA vaccines against infectious diseases such as COVID has opened new avenues for their application in oncology In cancer immunotherapy mRNA vaccinestypically encapsulated in lipid nanoparticles LNPs
