Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Understanding and Mitigating the Impact of Ambient mRNA Contamination in Single-cell RNA-sequencing Analysis
Dropletbased singlecell RNA sequencing scRNAseq frequently encounters significant challenges from contamination of cellfree mRNAs known as ambient mRNAs which can substantially distort singlecell transcriptome
Drug-induced Vitiligo: A real-world Pharmacovigilance Analysis of the FAERS Database
In recent years with the expanding use of novel therapeutics such as immune checkpoint inhibitors and monoclonal antibodies reports of druginduced vitiligo have been increasing This study aimed
A Cytotoxic Peptide-drug Conjugate for Tumor-specific Delivery of Co-injected Molecules
An ideal cancer therapy enhances antitumor effects while minimizing side effects iRGD a noncytotoxic peptide that activates a tumorspecific molecular transport machinery promotes the penetration of coinjected
Drug-induced Liver Injury Prediction Based on Graph Convolutional Networks and Toxicogenomics
Druginduced liver injury is a leading cause of high attrition rates for both candidate drugs and marketed medications Previous in silico models may not effectively utilize biological drug property information and often lack robust model validation In this study
Immune Signatures of SARS-CoV-2 Infection Resolution in Human Lung Tissues
While human autopsy samples have provided insights into pulmonary immune mechanisms associated with severe viral respiratory diseases the mechanisms that contribute to a clinically favorable resolution of viral respiratory infections remain unclear
Genetic Association of Lipids Characteristics and Lipid Lowering Drug Target Genes with Sepsis
Sepsis is a severe systemic infection that can result in organ dysfunction and mortality Dyslipidemia emerges as a key player in the intricate web of sepsis pathogenesis Yet the causal relationship between
Characterization of Multi-targeted Insulin-mimetic Antidiabetic Peptides Using in Silico Approaches
Diabetes is a metabolic disease that can affect people at any age Despite being one of the leading causes of death the treatment of diabetes is extremely difficult For the treatment of diabetes mellitus various
Novel Insights into Post-myocardial Infarction Cardiac Remodeling Through Algorithmic Detection of Cell-type Composition Shifts
Interpreting bulk RNA sequencing from heterogeneous tissues like the postmyocardial infarction MI heart is confounded by dynamic changes in celltype composition To address this we developed a computational approach
Phenotype to Genotype: A New and Rapid Approach Using Whole-genome Sequencing
Forward genetic screening is a powerful approach to assign functions to genes and can be used to elucidate the many genes whose functions remain unknown A key step in forward genetic screening is mapping
Single-cell Mutational Burden Distributions in Birth–death Processes
Genetic mutations are footprints of cancer evolution and reveal critical dynamic parameters of tumour growth which otherwise are hard to measure in vivo
