Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Characterization of Multi-targeted Insulin-mimetic Antidiabetic Peptides Using in Silico Approaches
Diabetes is a metabolic disease that can affect people at any age Despite being one of the leading causes of death the treatment of diabetes is extremely difficult For the treatment of diabetes mellitus various
Novel Insights into Post-myocardial Infarction Cardiac Remodeling Through Algorithmic Detection of Cell-type Composition Shifts
Interpreting bulk RNA sequencing from heterogeneous tissues like the postmyocardial infarction MI heart is confounded by dynamic changes in celltype composition To address this we developed a computational approach
Phenotype to Genotype: A New and Rapid Approach Using Whole-genome Sequencing
Forward genetic screening is a powerful approach to assign functions to genes and can be used to elucidate the many genes whose functions remain unknown A key step in forward genetic screening is mapping
Single-cell Mutational Burden Distributions in Birth–death Processes
Genetic mutations are footprints of cancer evolution and reveal critical dynamic parameters of tumour growth which otherwise are hard to measure in vivo
AI-first Structural Identification of Pathogenic Protein Target Interfaces
The risk of pandemics is increasing as global population growth and interconnectedness accelerate Understanding the structural basis of proteinprotein interactions between pathogens and hosts is critical
A Mathematical Framework for the Quantitative Analysis of Genetic Buffering
Genetic buffering plays a pivotal role in orchestrating the relationship between genotype and phenotype in outbred populations While highthroughput screens have identified many instances of genetic buffering
The Potential Global Health Impact and Cost-effectiveness of Next-generation Influenza Vaccines: A Modelling Analysis
Nextgeneration influenza vaccines NGIVs are in development and have the potential to achieve substantial reductions in influenza burden with resulting widespread health and economic benefits
Biomarkers of mRNA Vaccine Efficacy Derived from Mechanistic Modeling of Tumor-immune Interactions
The success of mRNA vaccines against infectious diseases such as COVID has opened new avenues for their application in oncology In cancer immunotherapy mRNA vaccinestypically encapsulated in lipid nanoparticles LNPs
Features Influencing the Health and Economic Impact of Preventing COVID-19 in Immunocompromised Individuals
Many immunocompromised individuals mount inadequate immune responses following COVID vaccination thus relying on other social distancing behaviours particularly shielding for protection impacting their quality of life
Long-term Anti-SARS-CoV-2 Antibody Trajectories After Neutralizing Monoclonal Antibody Treatment
Neutralizing monoclonal antibodies nMAbs have been used to treat COVID and are increasingly being used to treat other infections However there is concern that by neutralizing the SARSCoV virus
