Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
SARS-CoV-2 Neutralizing Antibodies Longevity, Breadth, and Evasion by Emerging Viral Variants
The Severe Acute Respiratory Syndrome Coronavirus SARSCoV antibody neutralization response and its evasion by emerging viral variants and variant of concern VOC are unknown but critical to understand reinfection risk and breakthrough infection following vaccination
Addressing Vaccine Hesitancy in Developing Countries: Survey and Experimental Evidence
Vaccine hesitancy is proving to be a significant impediment to COVID vaccination campaigns in some developing countries This study focuses on vaccine hesitancy and means of reducing it Data come from a large representative phone survey and online randomized survey experiment both run in Papua New Guinea a developing country
Synergistic Drug Combinations Designed to Fully Suppress SARS-CoV-2 in the Lung of COVID-19 Patients
Despite new antivirals are being approved against SARSCoV they suffer from significant constraints and are not indicated for hospitalized patients who are left with few antiviral options Repurposed drugs have previously shown controversial clinical results and it remains difficult to understand why certain trials delivered
Association of Serum Biomarkers with Early Neurologic Improvement after Intravenous Thrombolysis in Ischemic Stroke
Early neurologic improvement ENI after intravenous thrombolysis is associated with favorable outcome but associated serum biomarkers were not fully determined We aimed to investigate the issue based on a prospective cohort
DNA Damage and Antioxidant Capacity in COPD Patients with and without Lung Cancer
Chronic obstructive pulmonary disease COPD is characterized by chronic inflammation of the lower airways and COPD patients show two to five times higher risk of lung cancer than smokers with normal lung function COPD is associated with increased oxidative stress which may cause DNA damage and lung carcinogenesis
A New Machine Learning Method for Cancer Mutation Analysis
It is complicated to identify cancercausing mutations The recurrence of a mutation in patients remains one of the most reliable features of mutation driver status However some mutations are more likely to happen than others for various reasons Different sequencing analysis
Repositioning of Anti-dengue Compounds Against SARS-CoV-2 as Viral Polyprotein Processing Inhibitor
A therapy for COVID Coronavirus Disease caused by Severe Acute Respiratory Syndrome Coronavirus SARSCoV remains elusive due to the lack of an effective antiviral therapeutic molecule The SARSCoV main protease Mpro which plays a vital role in the viral life cycle
Transfer Learning for Non-image Data in Clinical Research: A Scoping Review
Transfer learning is a form of machine learning where a pretrained model trained on a specific task is reused as a starting point and tailored to another task in a different dataset While transfer learning has garnered considerable attention in medical image analysis its use for clinical nonimage data is not well studied Therefore the objective of...
Sequencing SARS-CoV-2 from Antigen Tests
Genomic surveillance empowers agile responses to SARSCoV by enabling scientists and public health analysts to issue recommendations aimed at slowing transmission prioritizing contact tracing and building a robust genomic sequencing surveillance strategy Since the start of the pandemic real time RTPCR diagnostic testing from upper
The Properties of Human Disease Mutations at Protein Interfaces
The assembly of proteins into complexes and their interactions with other biomolecules are often vital for their biological function While it is known that mutations at protein interfaces have a high potential to be damaging and cause human genetic disease there has been relatively
