Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
The Impact of the COVID-19 Pandemic on Scientific Research in the Life Sciences
The COVID outbreak has posed an unprecedented challenge to humanity and science On the one side public and private incentives have been put in place to promptly allocate resources toward research areas strictly related to the COVID emergency However research in many fields not directly related to the pandemic has been displaced In this paper we ass...
Itemization Difference of Patient-reported Outcome in Patients with Chronic Liver Disease
The itemization difference of patientreported outcome PRO in hepatitis patients with different etiologies remains elusive in Asia We aimed to assess the characteristics and the difference of healthrelated quality of life HRQoL in chronic hepatitis B CHB chronic hepatitis C CHC and nonalcoholic fatty liver disease NAFLD patients
Beyond Inclusion: Enacting Team Equity in Precision Medicine Research
To identify meanings of and challenges to enacting equitable diversification of genomics research and specifically precision medicine research PMR teams There have been resounding calls for increased workforce diversity WFD and greater inclusion of underrepresented researchers in genomics and academic science more broadly Growing awareness of syste...
Preparing for Patients with High-consequence Infectious Diseases: Example of a High-level Isolation Unit
Patients with highconsequence infectious diseases HCID are rare in Western Europe However highlevel isolation units HLIU must always be prepared for patient admission Case fatality rates of HCID can be reduced by providing optimal intensive care management We here describe a single centres preparation its embedding in the national context and the c...
Prediction of Clinical Trial Enrollment Rates
Clinical trials represent a critical milestone of translational and clinical sciences However poor recruitment to clinical trials has been a long standing problem affecting institutions all over the world One way to reduce the cost incurred by insufficient enrollment is to minimize initiating trials that are most likely to fall short of their enrol...
Persistence of SARS-CoV-2 total Immunoglobulins in a series of Convalescent Plasma and Blood Donors
The vast majority of COVID cases both symptomatic and asymptomatic develop immunity after COVID contagion Whether lasting differences exist between infection and vaccination boosted immunity is yet to be known The aim of this study was to determine how long total antiSARSCoV antibodies due to past infection persist in peripheral blood
Non-pharmacological Interventions for Bone Health after Stroke: A Systematic Review
The risk for hip fracture is quadrupled in stroke survivors compared to healthy individuals attributable mainly to falls and disuse osteoporosis in the paretic side A study by Ramnemark et al showed that fracture risk increased from in the first year after stroke to and after and years respectively Among stroke patients with unilateral persist...
Machine Learning Predicts Cancer Subtypes and Progression from Blood Immune Signatures
Clinical adoption of immune checkpoint inhibitors in cancer management has highlighted the interconnection between carcinogenesis and the immune system Immune cells are integral to the tumour microenvironment and can influence the outcome of therapies Better understanding of an individuals immune landscape may play an important role
Functional human genes typically exhibit epigenetic conservation
Recent DepMap CRISPRCas single gene disruptions have identified genes more essential to proliferation in tissue culture It would be valuable to translate these finding with measurements more practical for human tissues Here we show that DepMap essential genes and other literature curated functional
Roadmap for the use of Base Editors to Decipher Drug Mechanism of Action
CRISPR base editors are powerful tools for largescale mutagenesis studies This kind of approach can elucidate the mechanism of action of compounds a key process in drug discovery Here we explore the utility of base editors in an early drug discovery context focusing on Gprotein
