Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Non-pharmacological Interventions for Bone Health after Stroke: A Systematic Review
The risk for hip fracture is quadrupled in stroke survivors compared to healthy individuals attributable mainly to falls and disuse osteoporosis in the paretic side A study by Ramnemark et al showed that fracture risk increased from in the first year after stroke to and after and years respectively Among stroke patients with unilateral persist...
Machine Learning Predicts Cancer Subtypes and Progression from Blood Immune Signatures
Clinical adoption of immune checkpoint inhibitors in cancer management has highlighted the interconnection between carcinogenesis and the immune system Immune cells are integral to the tumour microenvironment and can influence the outcome of therapies Better understanding of an individuals immune landscape may play an important role
Functional human genes typically exhibit epigenetic conservation
Recent DepMap CRISPRCas single gene disruptions have identified genes more essential to proliferation in tissue culture It would be valuable to translate these finding with measurements more practical for human tissues Here we show that DepMap essential genes and other literature curated functional
Roadmap for the use of Base Editors to Decipher Drug Mechanism of Action
CRISPR base editors are powerful tools for largescale mutagenesis studies This kind of approach can elucidate the mechanism of action of compounds a key process in drug discovery Here we explore the utility of base editors in an early drug discovery context focusing on Gprotein
Multifunctional RNA-binding Proteins Influence mRNA Abundance and Translational Efficiency of Distinct Sets of Target Genes
RNAbinding proteins RBPs can regulate more than a single aspect of RNA metabolism We searched for such previously undiscovered multifunctionality within a set of RBPs by defining the predictive value of RBP abundance for the transcription and translation levels of known RBP target genes
RNA Editing Regulates lnc RNA Splicing in Human Early Embryo Development
RNA editing is a co or posttranscriptional modification through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after transcription Previous studies found that RNA editing may be critically involved in cancer and aging However the function of RNA editing in human early
Interpretable Machine Learning for High-dimensional Trajectories of Aging Health
We have built a computational model for individual aging trajectories of health and survival which contains physical functional and biological variables and is conditioned on demographic lifestyle and medical background information We combine techniques of modern machine learning with an interpretable interaction network where health
Modeling the Onset of Symptoms of COVID-19 Effects of SARS-CoV-2 Variant
Identifying order of symptom onset of infectious diseases might aid in differentiating symptomatic infections earlier in a population thereby enabling nonpharmaceutical interventions and reducing disease spread Previously we developed a mathematical model predicting the order of symptoms based on data from the initial outbreak
Immunogenicity and Safety of Primary Fractional-dose Yellow Fever Vaccine in Autoimmune Rheumatic Diseases
Brazil faced a yellow feverYF outbreak in and vaccination was considered for autoimmune rheumatic disease patientsARD with low immune suppression due to YF high mortality Yellow feverYF is an infectious disease caused by a Flavivirus Flaviviridae family Severe cases may evolve to bleeding disorders
Microsimulation Based Quantitative Analysis of COVID-19 Management Strategies
Pandemic management requires reliable and efficient dynamical simulation to predict and control disease spreading The COVID SARSCoV pandemic is mitigated by several nonpharmaceutical interventions but it is hard to predict which of these are the most effective for a given population
