Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
The impact of age on genetic risk for common diseases
Inherited genetic variation contributes to individual risk for many complex diseases and is increasingly being used for predictive patient stratification Previous work has shown that genetic factors are not equally relevant to human traits across age and other contexts
Rare variants regulate expression of nearby individual genes in multiple tissues
The rapid decrease in sequencing cost has enabled genetic studies to discover rare variants associated with complex diseases and traits Once this association is identified the next step is to understand the genetic mechanism of rare variants on how the variants influence diseases Similar to the hypothesis of common variants
Bioinformatics prediction of differential miRNAs in non-small cell lung cancer
Nonsmall cell lung cancer NSCLC accounts for of all lung cancers The drug resistance of NSCLC has clinically increased This study aimed to screen miRNAs associated with NSCLC using bioinformatics analysis We hope that the screened miRNA can provide a research direction for the subsequent treatment
A patient-oriented research approach to assessing patients’ and primary care physicians’ opinions on trauma-informed care
To gather patients and primary care physicians PCP opinions on traumainformed Care TIC and to investigate the acceptability of recommendations developed by patient family and physician advisors
Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium
Biopharmaceutical products BPs are widely used to treat autoimmune diseases but immunogenicity limits their efficacy for an important proportion of patients Our knowledge of patientrelated factors influencing the occurrence of antidrug antibodies ADAs is still limited
DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines
DNA supercoiling is essential for all living cells because it controls all processes involving DNA In bacteria global DNA supercoiling results from the opposing activities of topoisomerase I which relaxes DNA and DNA gyrase which compacts DNA These enzymes are widely conserved sharing amino acid identity between the closely related
BADAN-conjugated β-lactamases as biosensors for β-lactam antibiotic detection
Lactam antibiotic detection has significant implications in food safety control environmental monitoring and pharmacokinetics study Here we report the development of two BADANconjugated lactamases ECb and ECbNQ as sensitive biosensors for lactam antibiotic detection
Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors
The ataxia telangiectasia and Radrelated ATR protein kinase is a key regulator of the cellular response to DNA damage Due to increased amount of replication stress cancer cells heavily rely on ATR to complete DNA replication and cell cycle progression Thus ATR inhibition is an emerging target in cancer therapy
LPCAT1 enhances castration resistant prostate cancer progression via increased mRNA synthesis and PAF production
Our previously study shown that Lysophosphatidylcholine Acyltransferase LPCAT is overexpressed in castration resistant prostate cancer CRPC relative to primary prostate cancer PCa and androgen controls its expression via the Wnt signaling pathway While highly expressed in CRPC the role of LPCAT
A spectrum of verticality across genes
Lateral gene transfer LGT has impacted prokaryotic genome evolution yet the extent to which LGT compromises vertical evolution across individual genes and individual phyla is unknown as are the factors that govern LGT frequency across genes Estimating LGT frequency from tree comparisons is problematic when thousands of genomes
