Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Age at diagnosis, glycemic trajectories, and responses to oral glucose-lowering drugs in type 2 diabetes in Hong Kong
Lifetime glycemic exposure and its relationship with age at diagnosis in type diabetes TD are unknown Pharmacologic glycemic management strategies for youngonset TD age at diagnosis
Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years
Based on different genetic and environmental risk factors and histology it has been proposed that rheumatoid arthritis RA consists of types autoantibodypositive and autoantibodynegative RA However until now this remained hypothetical
Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections
There is disagreement about the level of asymptomatic severe acute respiratory syndrome coronavirus SARSCoV infection We conducted a living systematic review and metaanalysis to address three questions Amongst people who become infected with SARSCoV what proportion does not experience symptoms at all during their infection
Patterns of COVID-19 testing and mortality by race and ethnicity among United States veterans
There is growing concern that racial and ethnic minority communities around the world are experiencing a disproportionate burden of severe acute respiratory syndrome coronavirus SARSCoV infection and coronavirus disease COVID
Lymphocytic infiltration in stage II microsatellite stable colorectal tumors
Identifying stage II patients with colorectal cancer CRC at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity Recently the intensity and the quality of the host immune response in the tumor microenvironment
Circulating tumour DNA in metastatic breast cancer to guide clinical trial
Metastatic breast cancer mBC is a heterogenous disease with increasing availability of targeted therapies as well as emerging genomic markers of therapeutic resistance necessitating timely and accurate molecular characterization of disease
Partitioning stable and unstable expression level variation in cell populations: A theoretical framework and its application to the T cell receptor
Phenotypic variation in the copy number of gene products expressed by cells or tissues has been the focus of intense investigation To what extent the observed differences in cellular expression levels are persistent or transient is an intriguing question
Cell signaling model for arterial mechanobiology
Arterial growth and remodeling at the tissue level is driven by mechanobiological processes at cellular and subcellular levels Although it is widely accepted that cells seek to promote tissue homeostasis in response to biochemical and biomechanical cues
A novel single-cell based method for breast cancer prognosis
Breast cancer prognosis is challenging due to the heterogeneity of the disease Various computational methods using bulk RNAseq data have been proposed for breast cancer prognosis However these methods suffer from limited performances or ambiguous biological relevance
Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection
Antiretroviral therapy ART for HIV infection is lifelong Stopping therapy typically leads to the reignition of infection and progressive disease In a major breakthrough recent studies have shown that early initiation of ART can lead to sustained posttreatment control of viremia
