Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Advancing TB Drug Regimen Development Through Innovative Quantitative Translational Pharmacology Methods and Approaches
Summary The development of novel TB multidrug regimens that are more efficacious and of shorter induration requires a robust drug development pipeline Advances in quantitative modeling and simulation can be used to maximize the utility of patientlevel data from prior and contemporary clinical trials thus optimizing study design for antiTB regimens...
Relationships Between Mechanical Properties And Drug Release From Electrospun Fibers Of PCL And PLGA Blends
Abstract Electrospun nanofibers have the potential to achieve high drug loading and the ability to sustain drug release Mechanical properties of the drugincorporated fibers suggest the importance of drugpolymer interactions In this study we investigated the mechanical properties of electrospun polycaprolactone PCL and poly DLlacticcoglycolic
Adaptation Of Targeted Nanocarriers To Changing Requirements In Antimalarial Drug Delivery
Abstract The adaptation of existing antimalarial nanocarriers to new Plasmodium stages drugs targeting molecules or encapsulating structures is a strategy that can provide new nanotechnologybased costefficient therapies against malaria We have explored the modification of different liposome prototypes that had been developed in our group for the t...
Antimicrobial Drug Use In Primary Healthcare Clinics: A Retrospective Evaluation
Summary Objectives To examine the appropriateness of antibiotics prescribed for acute infection based on the Malaysian national antibiotic guidelines and the defined daily dose DDD system of the World Health Organization WHO This study also aimed to describe the factors influencing the drug use pattern
Investigator-initiated Clinical Trials Conducted By The Portuguese Clinical Research Infrastructure Network (PtCRIN)
Abstract Interventional clinical studies can provide the highest levels of evidence and generate significant results on specific investigational medicinal products or medical devices In order to have powerful studies attain unquestionable results and make significant discoveries the number of patients enrolled must be high Therefore multinational...
Antiepileptic Drugs In Development Pipeline: A Recent Update
Abstract Epilepsy is the most common neurological disorder which significantly affects the quality of life and poses a health as well as economic burden on society Epilepsy affects approximately million people in the world The present article reviews the scientific rationale brief pathophysiology of epilepsy and newer antiepileptic drugs which ar...
Mathematical Modelling to Guide Drug Development for Malaria Elimination
Mathematical models of the dynamics of a drug within the host are now frequently used to guide drug development These generally focus on assessing the efficacy and duration of response to guide patient therapy Increasingly antimalarial drugs are used at the population level to clear infections provide chemoprevention and to reduce onward transmissi...
In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System
Abstract The release rate of doxorubicin DOX from the drugdelivery system DDS DC Bead was studied by miniaturized in vitro methods freeflowing and sample reservoir The dependencies of the release mechanisms on in vitro system conditions were investigated experimentally and by theoretical modeling An inverse relationship was found between release...
Orally Disintegrating Films: A Modern Expansion In Drug Delivery System
Abstract Over the past few decades tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy safety and patient acceptability As discovery and development of new chemical agents is a complex expensive and time consuming process so recent trends are shifting toward designing and developing innovative drug de...
Insights into CYP2B6-mediated drug–drug interactions
Abstract Mounting evidence demonstrates that CYPB plays a much larger role in human drug metabolism than was previously believed The discovery of multiple important substrates of CYPB as well as polymorphic differences has sparked increasing interest in the genetic and xenobiotic factors contributing to the expression and function of the enzyme Th...
