Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Renal Drug Transporters And Their Significance In Drug–drug Interactions
Abstract The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites Renal drug transporters which are primarily located in the renal proximal tubules play an important role in tubular secretion and reabsorption of drug molecules in the kidney Tubular secretion is characterized by high clearance capacities broad subs...
Effectiveness Of A Novel Cellular Therapy To Treat Multidrug-resistant Tuberculosis
Abstract Introduction We urgently need novel treatments for multidrugresistant tuberculosis MDRTB Autologous mesenchymal stromal cell MSC infusion is one such possibility due to its potential to repair damaged lung tissue and boost immune responses We aimed to assess the effectiveness of MSC to impro
Evaluation Of Ion Exchange Processes In Drug-eluting Embolization Beads By Use Of An Improved Flow-through Elution Method
Abstract An improved method for evaluating drug release behaviour of drugeluting embolization beads DEBs was developed utilizing an openloop flowthrough system in which the beads were packed into an occlusive mass within the system and extracted with a flowing elution medium over time Glass beads were introduced into the beads mass in order to ens...
Spectrophotometric determination of Ethionamide in Pharmaceuticals using Folin-Ciocalteu reagent and Iron (III)-Ferricyanide as Chromogenic Agents
Abstract Two simple and sensitive spectrophotometric methods are described for the determination of ethionamide ETM in pure drug and tablets The first method is based on the reduction of FolinCiocalteu FC reagent by ETM in sodium carbonate medium to form a blue coloured complex which was measured at nm Molybdenumtungsten blue method In the second...
Discrete Event Simulation Modelling For Dynamic Decision Making In Biopharmaceutical Manufacturing
Abstract With the increase in demand for biopharmaceutical products industries have realised the need to scale up their manufacturing from laboratorybased processes to financially viable production processes In this context biopharmaceutical manufacturers are increasingly using simulationbased approaches to gain transparency of their current produ...
Antitubercular Drugs For An Old Target: GSK693 As A Promising InhA Direct Inhibitor
Abstract Despite being one of the first antitubercular agents identified isoniazid INH is still the most prescribed drug for prophylaxis and tuberculosis TB treatment and together with rifampicin the pillars of current chemotherapy A high percentage of isoniazid resistance is linked to mutations in the prodrug activating enzyme KatG so the discove...
Targeting Blood-brain-barrier Transcytosis – Perspectives For Drug Delivery
Abstract Efficient transcytosis across the bloodbrainbarrier BBB is an important strategy for accessing drug targets within the central nervous system CNS Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low In order to expand current research...
Thin Films As An Emerging Platform For Drug Delivery
Abstract Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool Thin films have been identified as an alternative approach to conventional dosage forms The thin films are considered to be convenient to swallow selfadministrable and fast dissolving dosage form all of which makes it as a versati...
In Silico Product Design Of Pharmaceuticals
Abstract The increasing demand for personalized medicine necessitates the production of easily customizable dosage forms As the number of possible dosage forms may scale toward infinity their uniqueness requires a versatile production platform and numerical simulation in order to be manufactured efficiently A mathematical description of these syst...
Changing Paradigms In Bioequivalence Trials Submitted To The Ema For Evaluation – A Clinical And Regulatory Perspective
Abstract Background The selection of a robust bioequivalence BE study designs for registering a generic product remains still a hard task This task is still challenging despite the fact that generic products are much needed by health care providers in economical terms Thus BE study designs could be a means to
