Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Assessing The Potential Of Mathematical Modelling In Designing Drug-releasing Orthopaedic Implants
Abstract Orthopaedic implants have been the subject of intense research in recent years with academics clinicians and industrialists seeking to broaden our understanding of their function and potential consequences within the human body Current research is focussed on ways to improve the integration of an orthopaedic device within the body whether...
Evaluation Of Giardia Lamblia Thioredoxin Reductase As Drug Activating Enzyme And As Drug Target
Abstract The antioxidative enzyme thioredoxin reductase TrxR has been suggested to be a drug target in several pathogens including the protist parasite Giardia lamblia TrxR is also believed to catalyse the reduction of nitro drugs eg metronidazole and furazolidone a reaction required to render these compounds toxic to G lamblia and other microaero...
Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics
Abstract Mycobacterium tuberculosis M tuberculosis is considered innately resistant to lactam antibiotics However there is evidence that susceptibility to lactam antibiotics in combination with lactamase inhibitors is variable among clinical isolates and these may present therapeutic options for drugresistant cases Here we report o
Cytokines In Cancer Drug Resistance: Cues To New Therapeutic Strategies
Abstract The development of oncoproteintargeted anticancer drugs is an invaluable weapon in the war against cancer However cancers do not give up without a fight They may develop multiple mechanisms of drug resistance including apoptosis inhibition drug expulsion and increased proliferation that reduce the effectiveness of the drug The collective...
An Update On The Role Of Intestinal Cytochrome P450 Enzymes In Drug Disposition
Abstract Oral administration is the most commonly used route for drug treatment Intestinal cytochrome P CYPmediated metabolism can eliminate a large proportion of some orally administered drugs before they reach systemic circulation while leaving the passage of other drugs unimpeded A better understanding of the ability of intestinal P enzymes to...
Loading Of Tacrolimus Containing Lipid Based Drug Delivery Systems Into Mesoporous Silica For Extended Release
Abstract Many studies had been focused on designing tacrolimus sustained release preparations based on solid dispersion technique but no one had tried to employ mesoporous silica as the carrier material to realize this goal The purpose of this study was to develop a novel simple and environmental friendly drug loading method with mesoporous silica...
Electrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery
Abstract Targeted delivery of potent toxic chemotherapy drugs such as cisplatin is a significant area of research in cancer treatment In this study cisplatin was successfully encapsulated with high efficiency in poly lacticcoglycolic acid polymeric nanoparticles by using electrohydrodynamic atomization EHDA where applied voltage and soluti
Exosomes As Therapeutic Drug Carriers And Delivery Vehicles Across Biological Membranes: Current Perspectives And Future Challenges
Abstract Exosomes are small intracellular membranebased vesicles with different compositions that are involved in several biological and pathological processes The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles exos...
In Situ Forming Hydrogels Based On Chitosan For Drug Delivery And Tissue Regeneration
Abstract In situ forming hydrogels with simple solgel transition are more practicable as injectable hydrogels for drug delivery and tissue regeneration Stateoftheart in situ gelling systems can easily and efficiently be formed by different mechanisms in situ Chitosan is a kind of natural polysaccharide that is widely exploited for biomedical appli...
Evaluation Of Three Amorphous Drug Delivery Technologies To Improve The Oral Absorption Of Flubendazole
Abstract This study investigates amorphous technologies to improve the dissolution rate and oral bioavailability of flubendazole FLU The selected approaches are a standard spraydried dispersion with hydroxypropylmethylcellulose HPMC E or polyvinylpyrrolidonevinyl acetate both with Vitamin E dtocopheryl polyethylene glycol succinate
