Research Insights
Research Insights section focuses on the cutting-edge and breakthrough research that is happening all over the world. Laboratories across the globe are working hard to develop drugs and therapies for various diseases and research insights directly from them add tremendous value.
Electrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery
Abstract Targeted delivery of potent toxic chemotherapy drugs such as cisplatin is a significant area of research in cancer treatment In this study cisplatin was successfully encapsulated with high efficiency in poly lacticcoglycolic acid polymeric nanoparticles by using electrohydrodynamic atomization EHDA where applied voltage and soluti
Exosomes As Therapeutic Drug Carriers And Delivery Vehicles Across Biological Membranes: Current Perspectives And Future Challenges
Abstract Exosomes are small intracellular membranebased vesicles with different compositions that are involved in several biological and pathological processes The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles exos...
In Situ Forming Hydrogels Based On Chitosan For Drug Delivery And Tissue Regeneration
Abstract In situ forming hydrogels with simple solgel transition are more practicable as injectable hydrogels for drug delivery and tissue regeneration Stateoftheart in situ gelling systems can easily and efficiently be formed by different mechanisms in situ Chitosan is a kind of natural polysaccharide that is widely exploited for biomedical appli...
Evaluation Of Three Amorphous Drug Delivery Technologies To Improve The Oral Absorption Of Flubendazole
Abstract This study investigates amorphous technologies to improve the dissolution rate and oral bioavailability of flubendazole FLU The selected approaches are a standard spraydried dispersion with hydroxypropylmethylcellulose HPMC E or polyvinylpyrrolidonevinyl acetate both with Vitamin E dtocopheryl polyethylene glycol succinate
New Agents For The Treatment Of Drug-resistant Mycobacterium Tuberculosis
Abstract Inadequate dosing and incomplete treatment regimens coupled with the ability of the tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs have fueled the rise of multidrugresistant tuberculosis MDRTB Treatment of MDRTB infections is a major clinical challenge that has few viable or effective solutions t...
Computational Approaches In Target Identification And Drug Discovery
Abstract In the big data era voluminous datasets are routinely acquired stored and analyzed with the aim to inform biomedical discoveries and validate hypotheses No doubt data volume and diversity have dramatically increased by the advent of new technologies and open data initiatives Big data are used across the whole drug discovery pipeline from...
A Review Of Global Initiatives To Fight Antibiotic Resistance And Recent Antibiotics' Discovery
Abstract Data from across the world have shown an overall decline in the antibiotic pipeline and continually rising resistance to all firstline and lastresort antibiotics The gaps in our knowledge of existing prevalence and mechanisms of antibiotic resistance ABR are all too well known Several decades of antibiotic abuse in humans animals and agri...
Investigation Of Salicylate Hepatic Responses In Comparison With Chemical Analogues Of The Drug
Abstract Antihyperglycaemic effects of the hydroxybenzoic acid salicylate might stem from effects of the drug on mitochondrial uncoupling activation of AMPactivated protein kinase and inhibition of NFB signalling Here we have gauged the contribution of these effects to control of hepatocyte glucose production comparing salicylate with inactive hyd...
Critical parameters in targeted drug development: the pharmacological audit trail
Abstract The Pharmacological Audit Trail PhAT comprises a set of critical questions that need to be asked during discovery and development of an anticancer drug Key aspects include defining a patient population establishing pharmacokinetic characteristics providing evidence of target engagement pathway modulation and biological effect with proo...
Charge-reversal Nanoparticles: Novel Targeted Drug Delivery Carriers
Abstract Spurred by significant progress in materials chemistry and drug delivery chargereversal nanocarriers are being developed to deliver anticancer formulations in spatial temporal and dosagecontrolled approaches Chargereversal nanoparticles can release their drug payload in response to specific stimuli that alter the charge on their surface T...
